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Phases of biomarker development for early detection of cancer.Journal of the National Cancer Institute, Vol. 93, No. 14. (18 July 2001), pp. 1054-1061.
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BibTeX record RIS record2dge aa aborigine abpm acarbose ace ace2 acei acetylation acid-base activity activity-based acute adenosine adipokine adiponectin adma adrenal adrenomedullin affinity affy aft age aging agreement ai aii akt album albumin alcohol aldh aldh2 aldosterone alignment alpk1 ampk amplification analgesics ancova androgen anemia aneurysm angiogenesis animal ann annexin anorexia anova anp ans anthropometry antibiotics antibody antisense apc apoe apoptosis appetite aptamer arb ards arecoline arf arkadia arthritis asia aspirin assocation association assumption asymptote at1 at2 atm attirtion attrition autoantibody autoimminity autoimmunity automation autophagy avf b2m bacteria bayes bcaa beta-adrenergic beta-blocker betel bia bias bifc bioamrker biobank biofilm bioinformatics bioinformatis biomaker biomarker biopsy blast bleeding blood bma bmi bmp bnp bone boosting bootstrap boratory bounded bp bun bv ca cachexia cachexmia cad cadium cadmium cage calcification calcimimetics calcium calorimetry calpain camp cancer candiate-gene candidate-gene canitine capd cardiomegaly carnitine case-cohort case-control caspase catabolism catenin catheter causality causation caveolin ccb cd ce cell cell-adhesion cell-array cell-cycle censor ceramide cgh cgmp change changepoiint changepoint chaqngepoint chd chemical-genetics chemogenomics chemokine chemotherapy chf china chip cho cholinergic chromatography ciliopathy ckd classification clathrin cloning cluster clustering cmv cnv co coffee cohort colchicine collagen collinearity colon comet communication comorbidity company compeitive-pcr competing-risk competitive-pcr competivie-pcr complex compliance confidence-interval confounding connexin control copper copula core-curriculum cortisol cost-efective cost-effect cost-effective cot-effective cotinine cox cox2 cqi creatinine creb cre-lox critical-care crossover cross-over cross-platform cross-species crp crrt cryopyrin ct ctgf curcumin cure cv cxcr2 cyclin cyp450 cyst cystatin cytokine cytoscape cytoskeleton database data-mining dataset dc decoy defensin delirium delivery dendritic-cell dentistry depression design dhplc diagnosis dialysate dialysis dialyzer diastolic dichotomization diet dige disease-management disparity distribution diuretics diurnal dm dn dna-damage dopamine dopps dose-reponse dose-response dpi drug drug-discovery dual duzzy dvt dye-swap e2f ebm ebv ecm ecology edema education effect-size effusion egf eia eicosanoid electrolyte electroporation electroportaion embryology emsa emt enamia endothelial-dysfunction endothelium endotoxin endpoint energy enoxacin ent environment enzyme epidemiology epigenetic epigenetics epistasis epithelium epo eqtl erk erm error er-stress est estrogen ethics exercise extraction fak family fasting fat fbat fc fdr fetal fetuin ffpe ffq fgf fhs fibrinogen fibroblast fibromyalgia fibrosis fish fish-oil flow-cytometry fluid fluorescence fly forest formaldehyde foxo fracpoly fractal frailty fret fructose fto function functional-regression function-regression futility fuzzy galectin gam gata gauss gb ge gee gencer gender gene gene-environment gene-gene gene-targeting gene-therapy genetics genome genomics geography gerd geriatric geriatrics gfr gh ghrelin gi gllamm glm glomerulus glucose glut glutamine glycation glycmoics glycomics gn gne-gene gnetics gof good gout gpcr graph graphics gremlin grid grn gsk gsk3 gst guideline gwa gyn gynecomastia haplotype hapmap hba1c hbv hcc hcv hcy hd hdac hdf hdl hematuria hemoglobin heparin hepatotyte herb heritability hfe hgf hgp hif hirsutism histone hmgb hnf ho ho1 hospital hospital-based hospitalization housekeeping hp hrs hsc hsp ht hts hwe hyaluronan hyperfiltration hyperglycemia hyperlipidemia hyperosmolality hypertfiltration hypertonicity hypertrophy hypotension hypoxia icp-ms icu id identifier idn idw ie ifn igf ih ihc il il1 il6 ilk illumina image imaging imcd immortal-time-bias immunity immunoblot immuno-pcr impuputation imputaion imputation indel inducible infection inflammasome inflammasone inflammation inflammtion influenza informative-censor insulin insulin-receptor integrin interaction interactome interval-censor intrumental-variable inverse-sampling ipcw ir iron irs itraq iv japan jnk joint-model jun k kallistatin keep kidney kinase kinin kinome kinomics klf klotho knockout label-free laboratory lactase lasso latent latent-class latent-growth lbp lc ldl lead left-censor leptin lft lifestyle lims linux liongitudinal lipid lipidomics lipid-signaling liver llcpk1 lna location lod logic-regression log-linear log-normal longitudinal low-density lox lpd lps lt lung lvh macrophage management mao mapk markov mars mashup matching mcp mcp1 mdr mds measurement measurement-error meat mediation megalin megsin melanocortin melting-curve membran membrane membrane-protein mendelian menin mercury mesangial met meta-analysis meta-anaysis meta-anlysis metabolism metabolomics metagenomics metal method methylation mg mgo mia mice microanalysis microaray microarrapy microarray microfludics microfluidics microscope milk mineral mirna missing mitochondria mixed-effect mixed-effects mixed-model mixed-modl mixture mkicroarray mmp model model-averaging model-organism model-selection molecular-beacon monotonic morality mortality mouse mrp mrsa msh msm msu mthfr mtor multinomial multiplex multiplicicy multiplicity multivariate mutagenesis mv myc myd88 myosin n na nac nahsit nail name nash necrosis nephrectomy nephrotoxicity network netwrok neuro neurology nfkb nhanes nhi niacin nitration nlr nmf nnt no nonlinear nonparametric normality normalization notch ntuh nuclear-medicine nuclear-receptor nucleoside nucleus nutrigenomics nutrition nutrtion oat obesity occupation oct oglcnac omics oncogene ontology ordinal osteopontin osteoporosis ou outcome outlier p p21 p2x p300 p38 p53 pad padlock pai1 pain palliative pathogenesis pathology pathway pbat pbmc pca pcr pd pde pdf pdgf pdk pdz pe pediatric pentoxifylline pentraxin periodontitis peritonitis pgc pharmacogenetics phd phenotype phosdphorylation phosphorylation phylogenetics pi pi3k pig pkc pla placebo plasmapheresis plasmid platelet pld pls pneumonia podocyte poisson polarity policy polyol pooling portal-ht power pp ppar ppara pparg ppi ppm1a prb prealbumin prediction pregnancy presentation prevention primer proliferation promoter propensity prostate protease proteasome protein protein-complex protein-microarray proteinuria proteomics pseudogene psychiatry pt pte pth ptm ptx pubmed pud p-value qol qtl quantitative r race radiology rage randomization rapamycin ras rat rbp rca rcr rct receptor recurrent recurrrent recutrrent reference reference-interval referral regeneration regression relaxin renalase renalse renin research retinoid reverse reverse-epidemiology rflp rho risk rnai robust roc ros rotein rppa rrf rt rtk s100 salicylate saliva salt sampling sarcopenia sarcopneia sas scaling screening seafood seasonal sem semantic semiparametric senescence sensitivity sensor sepsis sequence sequencing serotonin ses sex sga sglt signaling silymarin simulation single-cell single-molecule sirt sirt1 skin sle sleep smad smoking snail snake snon snp snx software sorting soy sp sparse splicing spline split-protein spss src staging standardization stat stata statin statistics stats std stem-cell stepwise steroid stoke stone strata stratification stress stroke structure stz subgroup sumo surgery surrogate survey survial-analysis survival survival-analysis svm sybr systems-biology systems-bioogy tag tag-snp taguchi taiwan taste tea telomere text-mining tf tg tgfb thiamine thyroid time time-course time-dependent tin tissue-microarray tissue-specific tissue-specificity tj tlr tma tnf tor toxic toxicology transcriptome transfection transformation transgenic transglutaminase translation treatment truncation tsp tumor-suppressor twin tyrk tzd ub ubiquitin ucp uf uirne ukm unx urate urate-transporter uremia urinalysis urine urokinase urology uti uuo vaccination validation variability vasopressin vegetable vegf vhl