GATA-1: one protein, many partners.

@article{citeulike:2920010, abstract = {GATA-1, the founding member of the GATA transcription factor family, is essential for cell maturation and differentiation within the erythroid and megakaryocytic lineages. GATA-1 regulates the expression of many genes within these lineages and its functionality depends upon its ability to bind both DNA and protein partners. Disruption of either of these functions causes severe hematopoietic dysfunction and results in blood disorders, such as thrombocytopenia and anemia. Within this review, we will focus on the structural aspects of GATA-1 with regard to interactions with its many partners and the identification of several mutations that disrupt these interactions.}, address = {School of Molecular and Microbial Biosciences, University of Sydney, Sydney, NSW 2006, Australia. j.lowry@mmb.usyd.edu.au}, author = {Lowry, J. A. and Mackay, J. P. }, citeulike-article-id = {2920010}, doi = {10.1016/j.biocel.2005.06.017}, issn = {1357-2725}, journal = {The international journal of biochemistry \& cell biology}, keywords = {gata}, month = {January}, number = {1}, pages = {6--11}, posted-at = {2008-06-24 03:14:13}, priority = {2}, title = {GATA-1: one protein, many partners.}, url = {http://dx.doi.org/10.1016/j.biocel.2005.06.017}, volume = {38}, year = {2006} }

TY - JOUR ID - citeulike:2920010 L3 - citeulike-article-id:2920010 TI - GATA-1: one protein, many partners. JF - The international journal of biochemistry & cell biology VL - 38 IS - 1 SP - 6 EP - 11 AD - School of Molecular and Microbial Biosciences, University of Sydney, Sydney, NSW 2006, Australia. j.lowry@mmb.usyd.edu.au SN - 1357-2725 N2 - GATA-1, the founding member of the GATA transcription factor family, is essential for cell maturation and differentiation within the erythroid and megakaryocytic lineages. GATA-1 regulates the expression of many genes within these lineages and its functionality depends upon its ability to bind both DNA and protein partners. Disruption of either of these functions causes severe hematopoietic dysfunction and results in blood disorders, such as thrombocytopenia and anemia. Within this review, we will focus on the structural aspects of GATA-1 with regard to interactions with its many partners and the identification of several mutations that disrupt these interactions. KW - gata AU - Lowry, JA AU - Mackay, JP PY - 2006/01// UR - http://dx.doi.org/10.1016/j.biocel.2005.06.017 ER -