Albumin excretion rate is not affected by asymptomatic urinary tract infection: a prospective study.

@article{citeulike:2873171, abstract = {OBJECTIVE: The aim of the study was to evaluate whether asymptomatic urinary tract infection (UTI) significantly influences the level of albumin excretion rate (AER) in diabetic patients. RESEARCH DESIGN AND METHODS: We screened prospectively for UTI and AER in 765 type 2 diabetic subjects. AER was determined before and after antimicrobial therapy in those patients in whom an asymptomatic UTI was diagnosed (n = 59). To interpret the clinical significance of AER changes, the coefficient of biological variation (CVb) of the AER (CVb-AER) was assessed in a control group of type 2 diabetic patients without UTI (n = 56). RESULTS: AER did not change after antimicrobial treatment either in the whole group of patients with UTI (pre: 13.8 microg/min [0.1-195] vs. post: 8.5 microg/min [0.1-185]; P = 0.1) or in those patients in whom the infection was eradicated (pre: 11.7 microg/min [0.1-195] vs. post: 7.1 microg/min [0.1-185]; NS). The CVb-AER was 64\% in the control group and was inversely correlated with AER (r = -0.44; P = 0.001). The decrease of AER after antimicrobial therapy (55\%) did not exceed the biological variation of AER (64\%). Finally, UTI did not significantly influence the classification of diabetic patients as normo- or microalbuminuric. CONCLUSIONS: Asymptomatic UTI does not increase AER in type 2 diabetic patients. Therefore, our results suggest that testing for UTI is not necessary when AER is measured in diabetic patients.}, address = {Diabetes Research Unit, Division of Endocrinology, Hospital Universitari Vall d'Hebron, Pg. Vall d'Hebron, Barcelona, Spain.}, author = {Hern\'{a}ndez, C. and Sim\'{o}, R. }, citeulike-article-id = {2873171}, issn = {0149-5992}, journal = {Diabetes care}, keywords = {proteinuria, uti}, month = {July}, number = {7}, pages = {1565--1569}, posted-at = {2008-06-08 06:52:30}, priority = {2}, title = {Albumin excretion rate is not affected by asymptomatic urinary tract infection: a prospective study.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/15220229}, volume = {27}, year = {2004} }

TY - JOUR ID - citeulike:2873171 L3 - citeulike-article-id:2873171 TI - Albumin excretion rate is not affected by asymptomatic urinary tract infection: a prospective study. JF - Diabetes care VL - 27 IS - 7 SP - 1565 EP - 1569 AD - Diabetes Research Unit, Division of Endocrinology, Hospital Universitari Vall d'Hebron, Pg. Vall d'Hebron, Barcelona, Spain. SN - 0149-5992 N2 - OBJECTIVE: The aim of the study was to evaluate whether asymptomatic urinary tract infection (UTI) significantly influences the level of albumin excretion rate (AER) in diabetic patients. RESEARCH DESIGN AND METHODS: We screened prospectively for UTI and AER in 765 type 2 diabetic subjects. AER was determined before and after antimicrobial therapy in those patients in whom an asymptomatic UTI was diagnosed (n = 59). To interpret the clinical significance of AER changes, the coefficient of biological variation (CVb) of the AER (CVb-AER) was assessed in a control group of type 2 diabetic patients without UTI (n = 56). RESULTS: AER did not change after antimicrobial treatment either in the whole group of patients with UTI (pre: 13.8 microg/min [0.1-195] vs. post: 8.5 microg/min [0.1-185]; P = 0.1) or in those patients in whom the infection was eradicated (pre: 11.7 microg/min [0.1-195] vs. post: 7.1 microg/min [0.1-185]; NS). The CVb-AER was 64% in the control group and was inversely correlated with AER (r = -0.44; P = 0.001). The decrease of AER after antimicrobial therapy (55%) did not exceed the biological variation of AER (64%). Finally, UTI did not significantly influence the classification of diabetic patients as normo- or microalbuminuric. CONCLUSIONS: Asymptomatic UTI does not increase AER in type 2 diabetic patients. Therefore, our results suggest that testing for UTI is not necessary when AER is measured in diabetic patients. KW - proteinuria KW - uti AU - Hernández, C AU - Simó, R PY - 2004/07// UR - http://view.ncbi.nlm.nih.gov/pubmed/15220229 ER -