Prediction of corticosteroid responsiveness based on fibroblast-specific protein 1 (FSP1) in patients with IgA nephropathy.

@article{citeulike:2868177, abstract = {BACKGROUND: Corticosteroids are frequently used to treat patients with active IgA nephropathy (IgAN); however, there have been few reports describing factors that are predictive of the response to corticosteroid treatment. Purpose. The purpose of this study is to determine the extent to which fibroblast-specific protein 1-positive (FSP1(+)) cells are predictive of corticosteroid responsiveness in patients with IgAN. Patients and Method. Fifty biopsy-proven IgAN patients who received corticosteroid therapy were enrolled and followed for 7.1 +/- 3.0 years. FSP1(+) cells were identified using an anti-FSP1 antibody. Result. Twelve patients showed progression of renal impairment or no reduction of urinary protein (non-responders) after steroid therapy. In the remaining 38 patients, renal function was stable during follow-up, and their urinary protein declined to <1.0 g/day (responders). Serum creatinine, estimated GFR, severity of mesangial proliferation, percent glomerulosclerosis/total glomeruli, extent of interstitial damage and FSP1(+) cell number were all significantly higher in non-responders than in responders. Cox regression analysis using two covariates with every possible combination of factors indicated that FSP1(+) cell number was the strongest and most significant predictor of corticosteroid responsiveness. When IgAN patients had >32.6 FSP1(+) cells/HPF at diagnosis, they were the more likely to show steroid resistance. CONCLUSION: FSP1(+) cell number can serve as an excellent predictor of corticosteroid responsiveness in patients with IgAN.}, address = {1st Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan.}, author = {Harada, Koji and Akai, Yasuhiro and Yamaguchi, Yukinari and Kimura, Kuniko and Nishitani, Yoshiharu and Nakatani, Kimihiko and Iwano, Masayuki and Saito, Yoshihiko }, citeulike-article-id = {2868177}, issn = {1460-2385}, journal = {Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association}, keywords = {fibroblast, gn}, month = {May}, posted-at = {2008-06-06 03:51:31}, priority = {2}, title = {Prediction of corticosteroid responsiveness based on fibroblast-specific protein 1 (FSP1) in patients with IgA nephropathy.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/18463322}, year = {2008} }

TY - JOUR ID - citeulike:2868177 L3 - citeulike-article-id:2868177 TI - Prediction of corticosteroid responsiveness based on fibroblast-specific protein 1 (FSP1) in patients with IgA nephropathy. JF - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association AD - 1st Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan. SN - 1460-2385 N2 - BACKGROUND: Corticosteroids are frequently used to treat patients with active IgA nephropathy (IgAN); however, there have been few reports describing factors that are predictive of the response to corticosteroid treatment. Purpose. The purpose of this study is to determine the extent to which fibroblast-specific protein 1-positive (FSP1(+)) cells are predictive of corticosteroid responsiveness in patients with IgAN. Patients and Method. Fifty biopsy-proven IgAN patients who received corticosteroid therapy were enrolled and followed for 7.1 +/- 3.0 years. FSP1(+) cells were identified using an anti-FSP1 antibody. Result. Twelve patients showed progression of renal impairment or no reduction of urinary protein (non-responders) after steroid therapy. In the remaining 38 patients, renal function was stable during follow-up, and their urinary protein declined to <1.0 g/day (responders). Serum creatinine, estimated GFR, severity of mesangial proliferation, percent glomerulosclerosis/total glomeruli, extent of interstitial damage and FSP1(+) cell number were all significantly higher in non-responders than in responders. Cox regression analysis using two covariates with every possible combination of factors indicated that FSP1(+) cell number was the strongest and most significant predictor of corticosteroid responsiveness. When IgAN patients had >32.6 FSP1(+) cells/HPF at diagnosis, they were the more likely to show steroid resistance. CONCLUSION: FSP1(+) cell number can serve as an excellent predictor of corticosteroid responsiveness in patients with IgAN. KW - fibroblast KW - gn AU - Harada, Koji AU - Akai, Yasuhiro AU - Yamaguchi, Yukinari AU - Kimura, Kuniko AU - Nishitani, Yoshiharu AU - Nakatani, Kimihiko AU - Iwano, Masayuki AU - Saito, Yoshihiko PY - 2008/05/07/ UR - http://view.ncbi.nlm.nih.gov/pubmed/18463322 ER -