The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts.

@article{citeulike:2824309, abstract = {High serum uric acid levels elevate pro-inflammatory-state gout crystal arthropathy and place individuals at high risk for cardiovascular morbidity and mortality. Genome-wide scans in the genetically isolated Sardinian population identified variants associated with serum uric acid levels as a quantitative trait. They mapped within GLUT9, a Chromosome 4 glucose transporter gene predominantly expressed in liver and kidney. SNP rs6855911 showed the strongest association (p = 1.84 x 10(-16)), along with eight others (p = 7.75 x 10(-16) to 6.05 x 10(-11)). Individuals homozygous for the rare allele of rs6855911 (minor allele frequency = 0.26) had 0.6 mg/dl less uric acid than those homozygous for the common allele; the results were replicated in an unrelated cohort from Tuscany. Our results suggest that polymorphisms in GLUT9 could affect glucose metabolism and uric acid synthesis and/or renal reabsorption, influencing serum uric acid levels over a wide range of values.}, address = {Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, United States of America.}, author = {Li, S. and Sanna, S. and Maschio, A. and Busonero, F. and Usala, G. and Mulas, A. and Lai, S. and Dei, M. and Orr\`{u}, M. and Albai, G. and Bandinelli, S. and Schlessinger, D. and Lakatta, E. and Scuteri, A. and Najjar, S. S. and Guralnik, J. and Naitza, S. and Crisponi, L. and Cao, A. and Abecasis, G. and Ferrucci, L. and Uda, M. and Chen, W. M. and Nagaraja, R. }, citeulike-article-id = {2824309}, doi = {http://dx.doi.org/10.1371/journal.pgen.0030194}, issn = {1553-7404}, journal = {PLoS genetics}, keywords = {snp, ua, urate-transporter}, month = {November}, number = {11}, posted-at = {2008-05-23 03:48:46}, priority = {2}, title = {The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts.}, url = {http://dx.doi.org/10.1371/journal.pgen.0030194}, volume = {3}, year = {2007} }

TY - JOUR ID - citeulike:2824309 L3 - citeulike-article-id:2824309 TI - The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts. JF - PLoS genetics VL - 3 IS - 11 AD - Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, United States of America. SN - 1553-7404 N2 - High serum uric acid levels elevate pro-inflammatory-state gout crystal arthropathy and place individuals at high risk for cardiovascular morbidity and mortality. Genome-wide scans in the genetically isolated Sardinian population identified variants associated with serum uric acid levels as a quantitative trait. They mapped within GLUT9, a Chromosome 4 glucose transporter gene predominantly expressed in liver and kidney. SNP rs6855911 showed the strongest association (p = 1.84 x 10(-16)), along with eight others (p = 7.75 x 10(-16) to 6.05 x 10(-11)). Individuals homozygous for the rare allele of rs6855911 (minor allele frequency = 0.26) had 0.6 mg/dl less uric acid than those homozygous for the common allele; the results were replicated in an unrelated cohort from Tuscany. Our results suggest that polymorphisms in GLUT9 could affect glucose metabolism and uric acid synthesis and/or renal reabsorption, influencing serum uric acid levels over a wide range of values. KW - snp KW - ua KW - urate-transporter AU - Li, S AU - Sanna, S AU - Maschio, A AU - Busonero, F AU - Usala, G AU - Mulas, A AU - Lai, S AU - Dei, M AU - Orrù, M AU - Albai, G AU - Bandinelli, S AU - Schlessinger, D AU - Lakatta, E AU - Scuteri, A AU - Najjar, SS AU - Guralnik, J AU - Naitza, S AU - Crisponi, L AU - Cao, A AU - Abecasis, G AU - Ferrucci, L AU - Uda, M AU - Chen, WM AU - Nagaraja, R PY - 2007/11// UR - http://dx.doi.org/10.1371/journal.pgen.0030194 ER -