Hyponatremia Treatment Guidelines 2007: Expert Panel Recommendations

by: Joseph G Verbalis, Stephen R Goldsmith, Arthur Greenberg, Robert W Schrier, Richard H Sterns

The American Journal of Medicine, Vol. 120, No. 11, Supplement 1. (November 2007), pp. S1-S21.

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Abstract

Although hyponatremia is a common, usually mild, and relatively asymptomatic disorder of electrolytes, acute severe hyponatremia can cause substantial morbidity and mortality, particularly in patients with concomitant disease. In addition, overly rapid correction of chronic hyponatremia can cause severe neurologic deficits and death, and optimal treatment strategies for such cases are not established. An expert panel assessed the potential contributions of aquaretic nonpeptide small-molecule arginine vasopressin receptor (AVPR) antagonists to hyponatremia therapies. This review presents their conclusions, including identification of appropriate treatment populations and possible future indications for aquaretic AVPR antagonists.

@article{citeulike:2807511, abstract = {Although hyponatremia is a common, usually mild, and relatively asymptomatic disorder of electrolytes, acute severe hyponatremia can cause substantial morbidity and mortality, particularly in patients with concomitant disease. In addition, overly rapid correction of chronic hyponatremia can cause severe neurologic deficits and death, and optimal treatment strategies for such cases are not established. An expert panel assessed the potential contributions of aquaretic nonpeptide small-molecule arginine vasopressin receptor (AVPR) antagonists to hyponatremia therapies. This review presents their conclusions, including identification of appropriate treatment populations and possible future indications for aquaretic AVPR antagonists.}, author = {Verbalis, Joseph G. and Goldsmith, Stephen R. and Greenberg, Arthur and Schrier, Robert W. and Sterns, Richard H. }, booktitle = {Hyponatremia Treatment Guidelines 2007: Expert Panel Recommendations}, citeulike-article-id = {2807511}, doi = {10.1016/j.amjmed.2007.09.001}, journal = {The American Journal of Medicine}, month = {November}, number = {11, Supplement 1}, pages = {S1--S21}, posted-at = {2008-05-17 14:22:43}, priority = {2}, title = {Hyponatremia Treatment Guidelines 2007: Expert Panel Recommendations}, url = {http://dx.doi.org/10.1016/j.amjmed.2007.09.001}, volume = {120}, year = {2007} }

RIS record

TY - JOUR ID - citeulike:2807511 L3 - citeulike-article-id:2807511 TI - Hyponatremia Treatment Guidelines 2007: Expert Panel Recommendations T2 - Hyponatremia Treatment Guidelines 2007: Expert Panel Recommendations JF - The American Journal of Medicine VL - 120 IS - 11, Supplement 1 SP - S1 EP - S21 N2 - Although hyponatremia is a common, usually mild, and relatively asymptomatic disorder of electrolytes, acute severe hyponatremia can cause substantial morbidity and mortality, particularly in patients with concomitant disease. In addition, overly rapid correction of chronic hyponatremia can cause severe neurologic deficits and death, and optimal treatment strategies for such cases are not established. An expert panel assessed the potential contributions of aquaretic nonpeptide small-molecule arginine vasopressin receptor (AVPR) antagonists to hyponatremia therapies. This review presents their conclusions, including identification of appropriate treatment populations and possible future indications for aquaretic AVPR antagonists. AU - Verbalis, Joseph AU - Goldsmith, Stephen AU - Greenberg, Arthur AU - Schrier, Robert AU - Sterns, Richard PY - 2007/11// UR - http://dx.doi.org/10.1016/j.amjmed.2007.09.001 ER -

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