Overweight, Obesity, and Elevated Serum Cystatin C Levels in Adults in the United States

@article{citeulike:2807502, abstract = {Background Although high body mass index (BMI) is a risk factor for hypertension, diabetes, and cardiovascular disease, limited data exist on the association of overweight and obesity with early stages of kidney disease.Methods Cross-sectional data for 5083 participants of the nationally representative Third National Health and Nutrition Examination Survey with an estimated glomerular filtration rate >= 60 mL/min/1.73 m2 without micro- or macroalbuminuria were analyzed to determine the association between BMI and elevated serum cystatin C. Normal weight, overweight, class I obesity, and class II to III obesity were defined as a BMI of 18.5 to 24.9 kg/m2, 25.0 to 29.9 kg/m2, 30.0 to 34.9 kg/m2, and >= 35.0 kg/m2, respectively. Elevated serum cystatin C was defined as >= 1.09 mg/L (>=99th percentile for participants 20-39 years of age without diabetes, hypertension, micro- or macroalbuminuria, or stage 3-5 chronic kidney disease).Results The age-standardized prevalence of elevated serum cystatin C was 9.6\%, 12.9\%, 17.4\%, and 21.5\% among adults of normal weight, overweight, class I obesity, and class II to III obesity, respectively (P trend < .001). After multivariate adjustment for demographics, behaviors, systolic blood pressure, and serum biomarkers, and compared with participants of normal weight, the odds ratio (95\% confidence interval) of elevated serum cystatin C was 1.46 (1.02-2.10) for overweight, 2.36 (1.56-3.57) for class I obesity, and 2.82 (1.56-5.11) for class II to III obesity.Conclusion A graded association exists between higher BMI and elevated serum cystatin C. Further research is warranted to assess whether reducing BMI favorably affects elevated serum cystatin C and the development of chronic kidney disease.}, author = {Muntner, Paul and Winston, Jonathan and Uribarri, Jaime and Mann, Devin and Fox, Caroline S. }, citeulike-article-id = {2807502}, doi = {http://dx.doi.org/10.1016/j.amjmed.2008.01.003}, journal = {The American Journal of Medicine}, month = {April}, number = {4}, pages = {341--348}, posted-at = {2008-05-17 14:14:26}, priority = {2}, title = {Overweight, Obesity, and Elevated Serum Cystatin C Levels in Adults in the United States}, url = {http://dx.doi.org/10.1016/j.amjmed.2008.01.003}, volume = {121}, year = {2008} }

TY - JOUR ID - citeulike:2807502 L3 - citeulike-article-id:2807502 TI - Overweight, Obesity, and Elevated Serum Cystatin C Levels in Adults in the United States JF - The American Journal of Medicine VL - 121 IS - 4 SP - 341 EP - 348 N2 - Background Although high body mass index (BMI) is a risk factor for hypertension, diabetes, and cardiovascular disease, limited data exist on the association of overweight and obesity with early stages of kidney disease.Methods Cross-sectional data for 5083 participants of the nationally representative Third National Health and Nutrition Examination Survey with an estimated glomerular filtration rate >= 60 mL/min/1.73 m2 without micro- or macroalbuminuria were analyzed to determine the association between BMI and elevated serum cystatin C. Normal weight, overweight, class I obesity, and class II to III obesity were defined as a BMI of 18.5 to 24.9 kg/m2, 25.0 to 29.9 kg/m2, 30.0 to 34.9 kg/m2, and >= 35.0 kg/m2, respectively. Elevated serum cystatin C was defined as >= 1.09 mg/L (>=99th percentile for participants 20-39 years of age without diabetes, hypertension, micro- or macroalbuminuria, or stage 3-5 chronic kidney disease).Results The age-standardized prevalence of elevated serum cystatin C was 9.6%, 12.9%, 17.4%, and 21.5% among adults of normal weight, overweight, class I obesity, and class II to III obesity, respectively (P trend < .001). After multivariate adjustment for demographics, behaviors, systolic blood pressure, and serum biomarkers, and compared with participants of normal weight, the odds ratio (95% confidence interval) of elevated serum cystatin C was 1.46 (1.02-2.10) for overweight, 2.36 (1.56-3.57) for class I obesity, and 2.82 (1.56-5.11) for class II to III obesity.Conclusion A graded association exists between higher BMI and elevated serum cystatin C. Further research is warranted to assess whether reducing BMI favorably affects elevated serum cystatin C and the development of chronic kidney disease. AU - Muntner, Paul AU - Winston, Jonathan AU - Uribarri, Jaime AU - Mann, Devin AU - Fox, Caroline PY - 2008/04// UR - http://dx.doi.org/10.1016/j.amjmed.2008.01.003 ER -