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A New Look at Cytokine Signaling

by: Alexander Zdanov, Alexander Wlodawer
Cell, Vol. 132, No. 2. (25 January 2008), pp. 179-181.


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Signal transduction is initiated when a cytokine binds to the extracellular domains of its receptors, bringing them together and triggering a complicated sequence of events inside the cell. In this issue, LaPorte et al. (2008) present crystal structures of three signaling complexes of the cytokines interleukin-4 and interleukin-13 with their receptors, showing how events taking place outside the cell may affect the specificity of signal transduction.


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