Cause of death in individuals with chronic HBV and/or HCV infection, a nationwide community-based register study.

@article{citeulike:2806674, abstract = {Studies on chronic viral hepatitis and mortality have often been made on selected populations or in high-endemic countries. The aim of this study was to investigate the causes of death and the mortality rates in the nationwide cohorts of people chronically infected with hepatitis B virus (HBV) and/or hepatitis C virus (HCV) in Sweden, a low-endemic country. All notifications on chronic HBV infection and HCV infection 1990-2003 were linked to the Cause of Death Register. A total of 9517 people with chronic HBV infection, 34 235 people with HCV infection and 1601 with chronic HBV-HCV co-infection were included, and the mean observation times were 6.4, 6.3 and 7.9 years, respectively. The mortality in the cohorts was compared with age- and gender-specific mortality in the general population and standardized mortality ratios (SMR) were calculated. All-cause mortality was significantly increased, SMR 2.3 (HBV), 5.8 (HCV) and 8.5 (HBV-HCV), with a great excess liver-related mortality in all cohorts, SMR 21.7, 35.5 and 46.2, respectively. In HCV and HBV-HCV infected there was an increased mortality due to drug-related psychiatric diagnoses (SMR: 20.7 and 27.6) and external causes (SMR: 12.4 and 11.4), predominantly at younger age. To conclude, this study demonstrated an increased all-cause mortality, with a great excess mortality from liver disease, in all cohorts. In people with HCV infection the highest excess mortality in younger ages was from drug-related and external reasons.}, address = {Department of Infectious Diseases, \"{O}rebro University Hospital, \"{O}rebro, Sweden.}, author = {Duberg, Ann-Sofi S. and T\"{o}rner, Anna and Daviðsd\'{o}ttir, L\'{o}a and Aleman, Soo and Blaxhult, Anders and Svensson, Ake and Hultcrantz, Rolf and B\"{a}ck, Erik and Ekdahl, Karl }, citeulike-article-id = {2806674}, doi = {10.1111/j.1365-2893.2008.00982.x}, issn = {1365-2893}, journal = {Journal of viral hepatitis}, month = {April}, posted-at = {2008-05-17 10:31:10}, priority = {2}, title = {Cause of death in individuals with chronic HBV and/or HCV infection, a nationwide community-based register study.}, url = {http://dx.doi.org/10.1111/j.1365-2893.2008.00982.x}, year = {2008} }

TY - JOUR ID - citeulike:2806674 L3 - citeulike-article-id:2806674 TI - Cause of death in individuals with chronic HBV and/or HCV infection, a nationwide community-based register study. JF - Journal of viral hepatitis AD - Department of Infectious Diseases, Örebro University Hospital, Örebro, Sweden. SN - 1365-2893 N2 - Studies on chronic viral hepatitis and mortality have often been made on selected populations or in high-endemic countries. The aim of this study was to investigate the causes of death and the mortality rates in the nationwide cohorts of people chronically infected with hepatitis B virus (HBV) and/or hepatitis C virus (HCV) in Sweden, a low-endemic country. All notifications on chronic HBV infection and HCV infection 1990-2003 were linked to the Cause of Death Register. A total of 9517 people with chronic HBV infection, 34 235 people with HCV infection and 1601 with chronic HBV-HCV co-infection were included, and the mean observation times were 6.4, 6.3 and 7.9 years, respectively. The mortality in the cohorts was compared with age- and gender-specific mortality in the general population and standardized mortality ratios (SMR) were calculated. All-cause mortality was significantly increased, SMR 2.3 (HBV), 5.8 (HCV) and 8.5 (HBV-HCV), with a great excess liver-related mortality in all cohorts, SMR 21.7, 35.5 and 46.2, respectively. In HCV and HBV-HCV infected there was an increased mortality due to drug-related psychiatric diagnoses (SMR: 20.7 and 27.6) and external causes (SMR: 12.4 and 11.4), predominantly at younger age. To conclude, this study demonstrated an increased all-cause mortality, with a great excess mortality from liver disease, in all cohorts. In people with HCV infection the highest excess mortality in younger ages was from drug-related and external reasons. AU - Duberg, Ann-Sofi AU - Törner, Anna AU - Daviðsdóttir, Lóa AU - Aleman, Soo AU - Blaxhult, Anders AU - Svensson, Ake AU - Hultcrantz, Rolf AU - Bäck, Erik AU - Ekdahl, Karl PY - 2008/04/04/ UR - http://dx.doi.org/10.1111/j.1365-2893.2008.00982.x ER -