Tenets of PTEN Tumor Suppression

@article{citeulike:2746129, abstract = {Since its discovery as the elusive tumor suppressor gene at the frequently mutated 10q23 locus, PTEN has been identified as lost or mutated in several sporadic and heritable tumor types. A decade of work has established that PTEN is a nonredundant phosphatase that is essential for regulating the highly oncogenic prosurvival PI3K/AKT signaling pathway. This review discusses emerging modes of PTEN function and regulation, and speculates about how manipulation of PTEN function could be used for cancer therapy.}, author = {Salmena, Leonardo and Carracedo, Arkaitz and Pandolfi, Pier P. }, citeulike-article-id = {2746129}, doi = {10.1016/j.cell.2008.04.013}, journal = {Cell}, month = {May}, number = {3}, pages = {403--414}, posted-at = {2008-05-17 13:03:58}, priority = {2}, title = {Tenets of PTEN Tumor Suppression}, url = {http://dx.doi.org/10.1016/j.cell.2008.04.013}, volume = {133}, year = {2008} }

TY - JOUR ID - citeulike:2746129 L3 - citeulike-article-id:2746129 TI - Tenets of PTEN Tumor Suppression JF - Cell VL - 133 IS - 3 SP - 403 EP - 414 N2 - Since its discovery as the elusive tumor suppressor gene at the frequently mutated 10q23 locus, PTEN has been identified as lost or mutated in several sporadic and heritable tumor types. A decade of work has established that PTEN is a nonredundant phosphatase that is essential for regulating the highly oncogenic prosurvival PI3K/AKT signaling pathway. This review discusses emerging modes of PTEN function and regulation, and speculates about how manipulation of PTEN function could be used for cancer therapy. AU - Salmena, Leonardo AU - Carracedo, Arkaitz AU - Pandolfi, Pier PY - 2008/05/02/ UR - http://dx.doi.org/10.1016/j.cell.2008.04.013 ER -