Eph-Ephrin Bidirectional Signaling in Physiology and Disease

by: Elena B Pasquale

Cell, Vol. 133, No. 1. (4 April 2008), pp. 38-52.

View FullText article

DOI, ScienceDirect

Reviews [Write a review of this article]

There are no reviews of this article

Find related articles from these CiteULike users

jyuh

Find related articles with these CiteULike tags

no-tag

Abstract

Receptor tyrosine kinases of the Eph family bind to cell surface-associated ephrin ligands on neighboring cells. The ensuing bidirectional signals have emerged as a major form of contact-dependent communication between cells. New findings reveal that Eph receptors and ephrins coordinate not only developmental processes but also the normal physiology and homeostasis of many adult organs. Imbalance of Eph/ephrin function may therefore contribute to a variety of diseases. The challenge now is to better understand the complex and seemingly paradoxical signaling mechanisms of Eph receptors and ephrins, which will enable effective strategies to target these proteins in the treatment of diseases such as diabetes and cancer.

@article{citeulike:2713326, abstract = {Receptor tyrosine kinases of the Eph family bind to cell surface-associated ephrin ligands on neighboring cells. The ensuing bidirectional signals have emerged as a major form of contact-dependent communication between cells. New findings reveal that Eph receptors and ephrins coordinate not only developmental processes but also the normal physiology and homeostasis of many adult organs. Imbalance of Eph/ephrin function may therefore contribute to a variety of diseases. The challenge now is to better understand the complex and seemingly paradoxical signaling mechanisms of Eph receptors and ephrins, which will enable effective strategies to target these proteins in the treatment of diseases such as diabetes and cancer.}, author = {Pasquale, Elena B. }, citeulike-article-id = {2713326}, doi = {10.1016/j.cell.2008.03.011}, journal = {Cell}, month = {April}, number = {1}, pages = {38--52}, posted-at = {2008-05-17 13:15:23}, priority = {2}, title = {Eph-Ephrin Bidirectional Signaling in Physiology and Disease}, url = {http://dx.doi.org/10.1016/j.cell.2008.03.011}, volume = {133}, year = {2008} }

RIS record

TY - JOUR ID - citeulike:2713326 L3 - citeulike-article-id:2713326 TI - Eph-Ephrin Bidirectional Signaling in Physiology and Disease JF - Cell VL - 133 IS - 1 SP - 38 EP - 52 N2 - Receptor tyrosine kinases of the Eph family bind to cell surface-associated ephrin ligands on neighboring cells. The ensuing bidirectional signals have emerged as a major form of contact-dependent communication between cells. New findings reveal that Eph receptors and ephrins coordinate not only developmental processes but also the normal physiology and homeostasis of many adult organs. Imbalance of Eph/ephrin function may therefore contribute to a variety of diseases. The challenge now is to better understand the complex and seemingly paradoxical signaling mechanisms of Eph receptors and ephrins, which will enable effective strategies to target these proteins in the treatment of diseases such as diabetes and cancer. AU - Pasquale, Elena PY - 2008/04/04/ UR - http://dx.doi.org/10.1016/j.cell.2008.03.011 ER -

RIS BibTeX