Peripheral blood level alterations of TIMP-1, MMP-2 and MMP-9 in patients with type 1 diabetes.

@article{citeulike:2628465, abstract = {AIM: To determine the plasma levels of enzymes and inhibitors involved in extracellular matrix turnover in patients with Type 1 diabetes with normal renal function. METHODS: Plasma levels of matrix metalloproteinases 2 and 9 (MMP-2, MMP-9) and tissue inhibitor of metalloproteinase 1 (TIMP-1) were measured in 43 Type 1 diabetic subjects and age- and sex-matched controls. RESULTS: No significant difference in plasma MMP-2 between diabetic patients and controls was observed. MMP-9 was detected in the plasma of 15 diabetic patients (35\%), but undetectable in all control subjects (P < 0.015). Plasma TIMP-1 concentrations were significantly elevated (P < 0.001) in diabetic patients compared to controls. There was no correlation observed between MMP-2, MMP-9 and TIMP-1 and similarly between MMP-2, MMP-9 and TIMP-1 and age, duration of diabetes, blood pressure and glycated haemoglobin (HbA1c). CONCLUSIONS: This study has demonstrated alterations in several plasma extracellular matrix modulators in the absence of significant vascular disease.}, address = {Department of Biochemistry Stobhill Hospital, Glasgow, Glasgow, UK. mxullo1969@netscapeonline.co.uk}, author = {Maxwell, P. R. and Timms, P. M. and Chandran, S. and Gordon, D. }, citeulike-article-id = {2628465}, issn = {0742-3071}, journal = {Diabetic medicine : a journal of the British Diabetic Association}, month = {October}, number = {10}, pages = {777--780}, posted-at = {2008-04-04 05:05:53}, priority = {2}, title = {Peripheral blood level alterations of TIMP-1, MMP-2 and MMP-9 in patients with type 1 diabetes.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/11678966}, volume = {18}, year = {2001} }

TY - JOUR ID - citeulike:2628465 L3 - citeulike-article-id:2628465 TI - Peripheral blood level alterations of TIMP-1, MMP-2 and MMP-9 in patients with type 1 diabetes. JF - Diabetic medicine : a journal of the British Diabetic Association VL - 18 IS - 10 SP - 777 EP - 780 AD - Department of Biochemistry Stobhill Hospital, Glasgow, Glasgow, UK. mxullo1969@netscapeonline.co.uk SN - 0742-3071 N2 - AIM: To determine the plasma levels of enzymes and inhibitors involved in extracellular matrix turnover in patients with Type 1 diabetes with normal renal function. METHODS: Plasma levels of matrix metalloproteinases 2 and 9 (MMP-2, MMP-9) and tissue inhibitor of metalloproteinase 1 (TIMP-1) were measured in 43 Type 1 diabetic subjects and age- and sex-matched controls. RESULTS: No significant difference in plasma MMP-2 between diabetic patients and controls was observed. MMP-9 was detected in the plasma of 15 diabetic patients (35%), but undetectable in all control subjects (P < 0.015). Plasma TIMP-1 concentrations were significantly elevated (P < 0.001) in diabetic patients compared to controls. There was no correlation observed between MMP-2, MMP-9 and TIMP-1 and similarly between MMP-2, MMP-9 and TIMP-1 and age, duration of diabetes, blood pressure and glycated haemoglobin (HbA1c). CONCLUSIONS: This study has demonstrated alterations in several plasma extracellular matrix modulators in the absence of significant vascular disease. AU - Maxwell, PR AU - Timms, PM AU - Chandran, S AU - Gordon, D PY - 2001/10// UR - http://view.ncbi.nlm.nih.gov/pubmed/11678966 ER -