The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

by: Ralph J Deberardinis, Julian J Lum, Georgia Hatzivassiliou, Craig B Thompson

Cell Metabolism, Vol. 7, No. 1. (9 January 2008), pp. 11-20.

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Abstract

Summary Cell proliferation requires nutrients, energy, and biosynthetic activity to duplicate all macromolecular components during each passage through the cell cycle. It is therefore not surprising that metabolic activities in proliferating cells are fundamentally different from those in nonproliferating cells. This review examines the idea that several core fluxes, including aerobic glycolysis, de novo lipid biosynthesis, and glutamine-dependent anaplerosis, form a stereotyped platform supporting proliferation of diverse cell types. We also consider regulation of these fluxes by cellular mediators of signal transduction and gene expression, including the phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR system, hypoxia-inducible factor 1 (HIF-1), and Myc, during physiologic cell proliferation and tumorigenesis.

@article{citeulike:2522711, abstract = {Summary Cell proliferation requires nutrients, energy, and biosynthetic activity to duplicate all macromolecular components during each passage through the cell cycle. It is therefore not surprising that metabolic activities in proliferating cells are fundamentally different from those in nonproliferating cells. This review examines the idea that several core fluxes, including aerobic glycolysis, de novo lipid biosynthesis, and glutamine-dependent anaplerosis, form a stereotyped platform supporting proliferation of diverse cell types. We also consider regulation of these fluxes by cellular mediators of signal transduction and gene expression, including the phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR system, hypoxia-inducible factor 1 (HIF-1), and Myc, during physiologic cell proliferation and tumorigenesis.}, author = {Deberardinis, Ralph J. and Lum, Julian J. and Hatzivassiliou, Georgia and Thompson, Craig B. }, citeulike-article-id = {2522711}, doi = {http://dx.doi.org/10.1016/j.cmet.2007.10.002}, journal = {Cell Metabolism}, keywords = {cancer}, month = {January}, number = {1}, pages = {11--20}, posted-at = {2008-06-15 00:51:46}, priority = {2}, title = {The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation}, url = {http://dx.doi.org/10.1016/j.cmet.2007.10.002}, volume = {7}, year = {2008} }

RIS record

TY - JOUR ID - citeulike:2522711 L3 - citeulike-article-id:2522711 TI - The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation JF - Cell Metabolism VL - 7 IS - 1 SP - 11 EP - 20 N2 - Summary Cell proliferation requires nutrients, energy, and biosynthetic activity to duplicate all macromolecular components during each passage through the cell cycle. It is therefore not surprising that metabolic activities in proliferating cells are fundamentally different from those in nonproliferating cells. This review examines the idea that several core fluxes, including aerobic glycolysis, de novo lipid biosynthesis, and glutamine-dependent anaplerosis, form a stereotyped platform supporting proliferation of diverse cell types. We also consider regulation of these fluxes by cellular mediators of signal transduction and gene expression, including the phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR system, hypoxia-inducible factor 1 (HIF-1), and Myc, during physiologic cell proliferation and tumorigenesis. KW - cancer AU - Deberardinis, Ralph AU - Lum, Julian AU - Hatzivassiliou, Georgia AU - Thompson, Craig PY - 2008/01/09/ UR - http://dx.doi.org/10.1016/j.cmet.2007.10.002 ER -

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