Gene expression-based screening for inhibitors of PDGFR signaling

by: Alena Antipova, Brent Stockwell, Todd Golub

Genome Biology, Vol. 9, No. 3. (2008)

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Abstract

Here we describe a proof-of-concept experiment designed to explore the possibility of using gene expression-based high throughput screening (GE-HTS) to find inhibitors of a signaling cascade, using platelet derived growth factor receptor (PDGFR) signaling as the example. Previously unrecognized ability of aurintricarboxylic acid (ATA) to inhibit PDGFR signaling, discovered through a screen of 1739 compounds, demonstrates the feasibility and generalizability of GE-HTS for the discovery of small molecule modulators of any signaling pathway of interest.

@article{citeulike:2457668, abstract = {Here we describe a proof-of-concept experiment designed to explore the possibility of using gene expression-based high throughput screening (GE-HTS) to find inhibitors of a signaling cascade, using platelet derived growth factor receptor (PDGFR) signaling as the example. Previously unrecognized ability of aurintricarboxylic acid (ATA) to inhibit PDGFR signaling, discovered through a screen of 1739 compounds, demonstrates the feasibility and generalizability of GE-HTS for the discovery of small molecule modulators of any signaling pathway of interest.}, author = {Antipova, Alena and Stockwell, Brent and Golub, Todd }, citeulike-article-id = {2457668}, doi = {http://dx.doi.org/10.1186/gb-2008-9-3-r47}, journal = {Genome Biology}, keywords = {microarray}, number = {3}, posted-at = {2008-05-18 03:10:29}, priority = {2}, title = {Gene expression-based screening for inhibitors of PDGFR signaling}, url = {http://dx.doi.org/10.1186/gb-2008-9-3-r47}, volume = {9}, year = {2008} }

RIS record

TY - JOUR ID - citeulike:2457668 L3 - citeulike-article-id:2457668 TI - Gene expression-based screening for inhibitors of PDGFR signaling JF - Genome Biology VL - 9 IS - 3 N2 - Here we describe a proof-of-concept experiment designed to explore the possibility of using gene expression-based high throughput screening (GE-HTS) to find inhibitors of a signaling cascade, using platelet derived growth factor receptor (PDGFR) signaling as the example. Previously unrecognized ability of aurintricarboxylic acid (ATA) to inhibit PDGFR signaling, discovered through a screen of 1739 compounds, demonstrates the feasibility and generalizability of GE-HTS for the discovery of small molecule modulators of any signaling pathway of interest. KW - microarray AU - Antipova, Alena AU - Stockwell, Brent AU - Golub, Todd PY - 2008/// UR - http://dx.doi.org/10.1186/gb-2008-9-3-r47 ER -

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