n-of-1 randomized controlled trials: an opportunity for complementary and alternative medicine evaluation.

@article{citeulike:2457459, abstract = {Complementary and alternative medicine (CAM) practice has traditionally relied on expert opinion and case examples to evaluate the outcome of a particular therapeutic treatment. Such trials are subject to bias, leading to the formation of erroneous conclusions about the effectiveness of most treatments. This paper reviews the feasibility of n-of-1 trials to better evaluate the clinical and statistical significance of CAM therapies. In particular: (1) problems arising from the use of standard therapeutic trials; (2) the n-of-1 trial and data analysis; (3) clinical use and advantages of the n-of-1 trial in conventional medicine; (4) potential clinical uses of the n-of-1 trial in CAM; (5) preliminary guidelines for the use of the n-of-1 trial in CAM; (6) constraints on the use of the n-of-1 trial in CAM; and (7) ethical issues in the conduct of the n-of-1 trial.}, address = {Complementary and Alternative Research and Education (CARE) Program, Department of Pediatrics, University of Alberta, Mackenzie Health Sciences Centre, Edmonton, Alberta T6G 2R7, Canada. b.johnston@ualberta.ca}, author = {Johnston, B. C. and Mills, E. }, citeulike-article-id = {2457459}, issn = {1075-5535}, journal = {J Altern Complement Med}, keywords = {herb, rct}, month = {December}, number = {6}, pages = {979--984}, posted-at = {2008-05-30 06:05:09}, priority = {2}, title = {n-of-1 randomized controlled trials: an opportunity for complementary and alternative medicine evaluation.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/15673992}, volume = {10}, year = {2004} }

TY - JOUR ID - citeulike:2457459 L3 - citeulike-article-id:2457459 TI - n-of-1 randomized controlled trials: an opportunity for complementary and alternative medicine evaluation. JF - J Altern Complement Med VL - 10 IS - 6 SP - 979 EP - 984 AD - Complementary and Alternative Research and Education (CARE) Program, Department of Pediatrics, University of Alberta, Mackenzie Health Sciences Centre, Edmonton, Alberta T6G 2R7, Canada. b.johnston@ualberta.ca SN - 1075-5535 N2 - Complementary and alternative medicine (CAM) practice has traditionally relied on expert opinion and case examples to evaluate the outcome of a particular therapeutic treatment. Such trials are subject to bias, leading to the formation of erroneous conclusions about the effectiveness of most treatments. This paper reviews the feasibility of n-of-1 trials to better evaluate the clinical and statistical significance of CAM therapies. In particular: (1) problems arising from the use of standard therapeutic trials; (2) the n-of-1 trial and data analysis; (3) clinical use and advantages of the n-of-1 trial in conventional medicine; (4) potential clinical uses of the n-of-1 trial in CAM; (5) preliminary guidelines for the use of the n-of-1 trial in CAM; (6) constraints on the use of the n-of-1 trial in CAM; and (7) ethical issues in the conduct of the n-of-1 trial. KW - herb KW - rct AU - Johnston, BC AU - Mills, E PY - 2004/12// UR - http://view.ncbi.nlm.nih.gov/pubmed/15673992 ER -