Gender difference in ICER Igamma transgenic diabetic mouse.

@article{citeulike:2420488, abstract = {Few studies have been done to examine gender differences in diabetic mouse models. Here we examined a gender difference in Inducible cAMP Early Repressor (ICER) transgenic (Tg) mice, a diabetic mouse model. Longitudinal changes in diabetes and nephropathy were investigated in male and female Tg mice. Both male and female Tg mice developed severe diabetes early in life due to severely impaired insulin synthesis and decreased beta-cell numbers, but only female Tg mice became less hyperglycemic later in life, and most female Tg mice did not develop diabetic nephropathy. Even some female Tg mice that remained hyperglycemic showed less renal expansion than age-matched male Tg mice. Thus the gender difference in the severity of diabetes and diabetic nephropathy was evident with age in this model. This study indicates that sex hormones may play a role in glucose metabolism in diabetic conditions.}, address = {Department of Diabetes and Clinical Nutrition, Kyoto University Graduate School of Medicine, Kyoto, Japan.}, author = {Inada, A. and Arai, H. and Nagai, K. and Miyazaki, J. and Yamada, Y. and Seino, Y. and Fukatsu, A. }, citeulike-article-id = {2420488}, issn = {0916-8451}, journal = {Biosci Biotechnol Biochem}, keywords = {dn, gender, mouse}, month = {August}, number = {8}, pages = {1920--1926}, posted-at = {2008-02-24 06:00:03}, priority = {2}, title = {Gender difference in ICER Igamma transgenic diabetic mouse.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/17690470}, volume = {71}, year = {2007} }

TY - JOUR ID - citeulike:2420488 L3 - citeulike-article-id:2420488 TI - Gender difference in ICER Igamma transgenic diabetic mouse. JF - Biosci Biotechnol Biochem VL - 71 IS - 8 SP - 1920 EP - 1926 AD - Department of Diabetes and Clinical Nutrition, Kyoto University Graduate School of Medicine, Kyoto, Japan. SN - 0916-8451 N2 - Few studies have been done to examine gender differences in diabetic mouse models. Here we examined a gender difference in Inducible cAMP Early Repressor (ICER) transgenic (Tg) mice, a diabetic mouse model. Longitudinal changes in diabetes and nephropathy were investigated in male and female Tg mice. Both male and female Tg mice developed severe diabetes early in life due to severely impaired insulin synthesis and decreased beta-cell numbers, but only female Tg mice became less hyperglycemic later in life, and most female Tg mice did not develop diabetic nephropathy. Even some female Tg mice that remained hyperglycemic showed less renal expansion than age-matched male Tg mice. Thus the gender difference in the severity of diabetes and diabetic nephropathy was evident with age in this model. This study indicates that sex hormones may play a role in glucose metabolism in diabetic conditions. KW - dn KW - gender KW - mouse AU - Inada, A AU - Arai, H AU - Nagai, K AU - Miyazaki, J AU - Yamada, Y AU - Seino, Y AU - Fukatsu, A PY - 2007/08// UR - http://view.ncbi.nlm.nih.gov/pubmed/17690470 ER -