Vitamin K and Vitamin D Status: Associations with Inflammatory Markers in the Framingham Offspring Study

@article{citeulike:2328127, abstract = {In vitro data suggest protective roles for vitamins K and D in inflammation. To examine associations between vitamins K and D and inflammation in vivo, the authors used multiple linear regression analyses, adjusted for age, sex, body mass index, triglyceride concentrations, use of aspirin, use of lipid-lowering medication, season, menopausal status, and hormone replacement therapy. Participants were from the Framingham Offspring Study (19972001; n = 1,381; mean age = 59 years; 52\% women). Vitamin K status, measured by plasma phylloquinone concentration and phylloquinone intake, was inversely associated with circulating inflammatory markers as a group and with several individual inflammatory biomarkers (p < 0.01). Percentage of undercarboxylated osteocalcin, a functional measure of vitamin K status, was not associated with overall inflammation but was associated with C-reactive protein (p < 0.01). Although plasma 25-hydroxyvitamin D was inversely associated with urinary isoprostane concentration, an indicator of oxidative stress (p < 0.01), overall associations between vitamin D status and inflammation were inconsistent. The observation that high vitamin K status was associated with lower concentrations of inflammatory markers suggests that a possible protective role for vitamin K in inflammation merits further investigation. 10.1093/aje/kwm306}, author = {Shea, Kyla M. and Booth, Sarah L. and Massaro, Joseph M. and Jacques, Paul F. and D'Agostino, Ralph B. and Dawson-Hughes, Bess and Ordovas, Jose M. and O'Donnell, Christopher J. and Kathiresan, Sekar and Keaney, John F. and Vasan, Ramachandran S. and Benjamin, Emelia J. }, citeulike-article-id = {2328127}, doi = {10.1093/aje/kwm306}, journal = {Am. J. Epidemiol.}, keywords = {inflammation, vitamin-d}, month = {February}, number = {3}, pages = {313--320}, posted-at = {2008-02-04 04:06:00}, priority = {2}, title = {Vitamin K and Vitamin D Status: Associations with Inflammatory Markers in the Framingham Offspring Study}, url = {http://dx.doi.org/10.1093/aje/kwm306}, volume = {167}, year = {2008} }

TY - JOUR ID - citeulike:2328127 L3 - citeulike-article-id:2328127 TI - Vitamin K and Vitamin D Status: Associations with Inflammatory Markers in the Framingham Offspring Study JF - Am. J. Epidemiol. VL - 167 IS - 3 SP - 313 EP - 320 N2 - In vitro data suggest protective roles for vitamins K and D in inflammation. To examine associations between vitamins K and D and inflammation in vivo, the authors used multiple linear regression analyses, adjusted for age, sex, body mass index, triglyceride concentrations, use of aspirin, use of lipid-lowering medication, season, menopausal status, and hormone replacement therapy. Participants were from the Framingham Offspring Study (19972001; n = 1,381; mean age = 59 years; 52% women). Vitamin K status, measured by plasma phylloquinone concentration and phylloquinone intake, was inversely associated with circulating inflammatory markers as a group and with several individual inflammatory biomarkers (p < 0.01). Percentage of undercarboxylated osteocalcin, a functional measure of vitamin K status, was not associated with overall inflammation but was associated with C-reactive protein (p < 0.01). Although plasma 25-hydroxyvitamin D was inversely associated with urinary isoprostane concentration, an indicator of oxidative stress (p < 0.01), overall associations between vitamin D status and inflammation were inconsistent. The observation that high vitamin K status was associated with lower concentrations of inflammatory markers suggests that a possible protective role for vitamin K in inflammation merits further investigation. 10.1093/aje/kwm306 KW - inflammation KW - vitamin-d AU - Shea, Kyla AU - Booth, Sarah AU - Massaro, Joseph AU - Jacques, Paul AU - D'Agostino, Ralph AU - Dawson-Hughes, Bess AU - Ordovas, Jose AU - O'Donnell, Christopher AU - Kathiresan, Sekar AU - Keaney, John AU - Vasan, Ramachandran AU - Benjamin, Emelia PY - 2008/02/01/ UR - http://dx.doi.org/10.1093/aje/kwm306 ER -