Control by cholinergic mechanisms.

by: K Racké, UR Juergens, S Matthiesen

Eur J Pharmacol, Vol. 533, No. 1-3. (8 March 2006), pp. 57-68.

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Abstract

In the respiratory tract acetylcholine is neurotransmitter in ganglia and postganglionic parasympathetic nerves, but in addition is paracrine mediator released from various non-neuronal cells. Almost every cell type present in the respiratory tract expresses nicotinic and muscarinic receptors and therefore appears to be a target for acetylcholine. The present review describes the mechanisms of synthesis and release of acetylcholine from neuronal and non-neuronal cells and the differential control mechanisms. The different cholinoceptors, multiple nicotinic and muscarinic receptors and their signalling are outlined and their involvement in the modulation of the function of various target cells, smooth muscles, nerves, surface epithelial, secretory cells, fibroblasts and inflammatory cells is discussed in detail.

@article{citeulike:2278681, abstract = {In the respiratory tract acetylcholine is neurotransmitter in ganglia and postganglionic parasympathetic nerves, but in addition is paracrine mediator released from various non-neuronal cells. Almost every cell type present in the respiratory tract expresses nicotinic and muscarinic receptors and therefore appears to be a target for acetylcholine. The present review describes the mechanisms of synthesis and release of acetylcholine from neuronal and non-neuronal cells and the differential control mechanisms. The different cholinoceptors, multiple nicotinic and muscarinic receptors and their signalling are outlined and their involvement in the modulation of the function of various target cells, smooth muscles, nerves, surface epithelial, secretory cells, fibroblasts and inflammatory cells is discussed in detail.}, address = {Institute of Pharmacology and Toxicology, University of Bonn, Reuterstrasse 2b, D-53113 Bonn, Germany. racke.kurt@uni-bonn.de}, author = {Rack\'{e}, K. and Juergens, U. R. and Matthiesen, S. }, citeulike-article-id = {2278681}, doi = {10.1016/j.ejphar.2005.12.050}, issn = {0014-2999}, journal = {Eur J Pharmacol}, month = {March}, number = {1-3}, pages = {57--68}, posted-at = {2008-01-23 03:18:36}, priority = {2}, title = {Control by cholinergic mechanisms.}, url = {http://dx.doi.org/10.1016/j.ejphar.2005.12.050}, volume = {533}, year = {2006} }

RIS record

TY - JOUR ID - citeulike:2278681 L3 - citeulike-article-id:2278681 TI - Control by cholinergic mechanisms. JF - Eur J Pharmacol VL - 533 IS - 1-3 SP - 57 EP - 68 AD - Institute of Pharmacology and Toxicology, University of Bonn, Reuterstrasse 2b, D-53113 Bonn, Germany. racke.kurt@uni-bonn.de SN - 0014-2999 N2 - In the respiratory tract acetylcholine is neurotransmitter in ganglia and postganglionic parasympathetic nerves, but in addition is paracrine mediator released from various non-neuronal cells. Almost every cell type present in the respiratory tract expresses nicotinic and muscarinic receptors and therefore appears to be a target for acetylcholine. The present review describes the mechanisms of synthesis and release of acetylcholine from neuronal and non-neuronal cells and the differential control mechanisms. The different cholinoceptors, multiple nicotinic and muscarinic receptors and their signalling are outlined and their involvement in the modulation of the function of various target cells, smooth muscles, nerves, surface epithelial, secretory cells, fibroblasts and inflammatory cells is discussed in detail. AU - Racké, K AU - Juergens, UR AU - Matthiesen, S PY - 2006/03/08/ UR - http://dx.doi.org/10.1016/j.ejphar.2005.12.050 ER -

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