Familial Risk Factors for Microvascular Complications And Differential Male-Female Risk in a Large Cohort of American Families with Type 1 Diabetes.

@article{citeulike:1862969, abstract = {Context: Type 1 diabetes (T1D) complications are responsible for much of the disease morbidity. Evidence suggests that familial factors exert an influence on susceptibility to complications. Objectives: We investigated familial risk factors and gender differences for retinopathy, nephropathy and neuropathy. Design and setting: Case-control design nested on a cohort of T1D families. We collected data (questionnaire, medical records) starting in1988. Follow-up has been on-going since 2004. Patients: There were 8114 T1D patients among 6707 families. All patients had T1D onset age <30 and required insulin treatment. Patients who remained without a complication after >15 years of diabetes were considered to be without that complication for our analyses. Results: A complication in a sibling increased the risk for that complication among probands: OR 9.9 (P<0.001) for retinopathy, 6.2 for nephropathy (P<0.001) and 2.2 for neuropathy (P<0.05). Compared to male probands, a female T1D proband had 1.7 fold higher retinopathy risk (P<0.001) and 2 fold higher neuropathy risk (P<0.001). T1D cases with onset between ages 5-14 had increased complications risk compared to subjects diagnosed either at a very young age or post-puberty. The presence of one complication significantly increased the risk for others. If a parent had type 2 diabetes, the risk for nephropathy increased (OR: 1.9, P<0.01) (but T1D in a parent did not increase the risk). Conclusions: We confirmed that familial factors influence T1D microvascular pathologies, suggesting a shared genetic basis for complications, perhaps independent of T1D susceptibility. We also found an unexpected increased female risk for complications.}, address = {Division of Statistical Genetics, Dept. of Biostatistics and Department of Psychiatry, Columbia University, NY, NY; National Disease Research Interchange, Philadelphia, PA; Section of Medical Statistics and Epidemiology, Dept. of Health Sciences, University of Pavia, Italy; and New York State Psychiatric Institute, NY, NY.}, author = {Monti, Maria C C. and Lonsdale, John T T. and Montomoli, Cristina and Montross, Rebecca and Schlag, Erin and Greenberg, David A A. }, citeulike-article-id = {1862969}, doi = {10.1210/jc.2007-1185}, issn = {0021-972X}, journal = {J Clin Endocrinol Metab}, keywords = {heritability}, month = {September}, posted-at = {2007-11-04 04:27:40}, priority = {2}, title = {Familial Risk Factors for Microvascular Complications And Differential Male-Female Risk in a Large Cohort of American Families with Type 1 Diabetes.}, url = {http://dx.doi.org/10.1210/jc.2007-1185}, year = {2007} }

TY - JOUR ID - citeulike:1862969 L3 - citeulike-article-id:1862969 TI - Familial Risk Factors for Microvascular Complications And Differential Male-Female Risk in a Large Cohort of American Families with Type 1 Diabetes. JF - J Clin Endocrinol Metab AD - Division of Statistical Genetics, Dept. of Biostatistics and Department of Psychiatry, Columbia University, NY, NY; National Disease Research Interchange, Philadelphia, PA; Section of Medical Statistics and Epidemiology, Dept. of Health Sciences, University of Pavia, Italy; and New York State Psychiatric Institute, NY, NY. SN - 0021-972X N2 - Context: Type 1 diabetes (T1D) complications are responsible for much of the disease morbidity. Evidence suggests that familial factors exert an influence on susceptibility to complications. Objectives: We investigated familial risk factors and gender differences for retinopathy, nephropathy and neuropathy. Design and setting: Case-control design nested on a cohort of T1D families. We collected data (questionnaire, medical records) starting in1988. Follow-up has been on-going since 2004. Patients: There were 8114 T1D patients among 6707 families. All patients had T1D onset age <30 and required insulin treatment. Patients who remained without a complication after >15 years of diabetes were considered to be without that complication for our analyses. Results: A complication in a sibling increased the risk for that complication among probands: OR 9.9 (P<0.001) for retinopathy, 6.2 for nephropathy (P<0.001) and 2.2 for neuropathy (P<0.05). Compared to male probands, a female T1D proband had 1.7 fold higher retinopathy risk (P<0.001) and 2 fold higher neuropathy risk (P<0.001). T1D cases with onset between ages 5-14 had increased complications risk compared to subjects diagnosed either at a very young age or post-puberty. The presence of one complication significantly increased the risk for others. If a parent had type 2 diabetes, the risk for nephropathy increased (OR: 1.9, P<0.01) (but T1D in a parent did not increase the risk). Conclusions: We confirmed that familial factors influence T1D microvascular pathologies, suggesting a shared genetic basis for complications, perhaps independent of T1D susceptibility. We also found an unexpected increased female risk for complications. KW - heritability AU - Monti, Maria C AU - Lonsdale, John T AU - Montomoli, Cristina AU - Montross, Rebecca AU - Schlag, Erin AU - Greenberg, David A PY - 2007/09/18/ UR - http://dx.doi.org/10.1210/jc.2007-1185 ER -