Biomarkers of Acute Kidney Injury.

@article{citeulike:1838588, abstract = {blacksquare, square, filled Abstract Acute kidney injury (AKI) is a common condition with a high risk of death. The standard metrics used to define and monitor the progression of AKI, such as serum creatinine and blood urea nitrogen levels, are insensitive, nonspecific, and change significantly only after significant kidney injury and then with a substantial time delay. This delay in diagnosis not only prevents timely patient management decisions, including administration of putative therapeutic agents, but also significantly affects the preclinical evaluation of toxicity thereby allowing potentially nephrotoxic drug candidates to pass the preclinical safety criteria only to be found to be clinically nephrotoxic with great human costs. Studies to establish effective therapies for AKI will be greatly facilitated by two factors: (a) development of sensitive, specific, and reliable biomarkers for early diagnosis/prognosis of AKI in preclinical and clinical studies, and (b) development and validation of high-throughput innovative technologies that allow rapid multiplexed detection of multiple markers at the bedside. Expected final online publication date for the Annual Review of Pharmacology and Toxicology Volume 48 is January 6, 2008. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates.}, address = {Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115 vvaidya@partners.org.}, author = {Vaidya, Vishal S S. and Ferguson, Michael A A. and Bonventre, Joseph V V. }, citeulike-article-id = {1838588}, doi = {http://dx.doi.org/10.1146/annurev.pharmtox.48.113006.094615}, issn = {0362-1642}, journal = {Annu Rev Pharmacol Toxicol}, keywords = {arf, biomarker}, month = {October}, posted-at = {2007-10-30 03:52:20}, priority = {2}, title = {Biomarkers of Acute Kidney Injury.}, url = {http://dx.doi.org/10.1146/annurev.pharmtox.48.113006.094615}, year = {2007} }

TY - JOUR ID - citeulike:1838588 L3 - citeulike-article-id:1838588 TI - Biomarkers of Acute Kidney Injury. JF - Annu Rev Pharmacol Toxicol AD - Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115 vvaidya@partners.org. SN - 0362-1642 N2 - blacksquare, square, filled Abstract Acute kidney injury (AKI) is a common condition with a high risk of death. The standard metrics used to define and monitor the progression of AKI, such as serum creatinine and blood urea nitrogen levels, are insensitive, nonspecific, and change significantly only after significant kidney injury and then with a substantial time delay. This delay in diagnosis not only prevents timely patient management decisions, including administration of putative therapeutic agents, but also significantly affects the preclinical evaluation of toxicity thereby allowing potentially nephrotoxic drug candidates to pass the preclinical safety criteria only to be found to be clinically nephrotoxic with great human costs. Studies to establish effective therapies for AKI will be greatly facilitated by two factors: (a) development of sensitive, specific, and reliable biomarkers for early diagnosis/prognosis of AKI in preclinical and clinical studies, and (b) development and validation of high-throughput innovative technologies that allow rapid multiplexed detection of multiple markers at the bedside. Expected final online publication date for the Annual Review of Pharmacology and Toxicology Volume 48 is January 6, 2008. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates. KW - arf KW - biomarker AU - Vaidya, Vishal S AU - Ferguson, Michael A AU - Bonventre, Joseph V PY - 2007/10/15/ UR - http://dx.doi.org/10.1146/annurev.pharmtox.48.113006.094615 ER -