p66(shc) is highly expressed in fibroblasts from centenarians.

@article{citeulike:1809692, abstract = {p66(shc-/-) mice exhibit prolonged lifespan and increased resistance to oxidative and hypoxic stress. To investigate p66(shc) involvement in human longevity, p66(shc) mRNA and protein were evaluated in fibroblasts from young people, elderly and centenarians, exposed to oxidative or hypoxic stress. Unexpectedly, centenarians showed the highest basal levels of p66(shc). Oxidative stress induced p66(shc) in all samples. At variance, hypoxic stress caused p66(shc) reduction only in cells from centenarians. These changes occurred in absence of any modification of p66(shc) promoter methylation pattern. Intriguingly, in cells from centenarians, p66(shc) induction was affected by p53 codon 72 polymorphism. Thus, cells from centenarians present a peculiar regulation of p66(shc), suggesting that its role in mammalian longevity is more complex than previously thought.}, address = {Department of Experimental Pathology, University of Bologna, via S. Giacomo 12, 40126 Bologna, Italy.}, author = {Pandolfi, S. and Bonaf\`{e}, M. and Di Tella, L. and Tiberi, L. and Salvioli, S. and Monti, D. and Sorbi, S. and Franceschi, C. }, citeulike-article-id = {1809692}, doi = {10.1016/j.mad.2005.03.004}, issn = {0047-6374}, journal = {Mech Ageing Dev}, month = {August}, number = {8}, pages = {839--844}, posted-at = {2007-10-23 09:29:34}, priority = {2}, title = {p66(shc) is highly expressed in fibroblasts from centenarians.}, url = {http://dx.doi.org/10.1016/j.mad.2005.03.004}, volume = {126}, year = {2005} }

TY - JOUR ID - citeulike:1809692 L3 - citeulike-article-id:1809692 TI - p66(shc) is highly expressed in fibroblasts from centenarians. JF - Mech Ageing Dev VL - 126 IS - 8 SP - 839 EP - 844 AD - Department of Experimental Pathology, University of Bologna, via S. Giacomo 12, 40126 Bologna, Italy. SN - 0047-6374 N2 - p66(shc-/-) mice exhibit prolonged lifespan and increased resistance to oxidative and hypoxic stress. To investigate p66(shc) involvement in human longevity, p66(shc) mRNA and protein were evaluated in fibroblasts from young people, elderly and centenarians, exposed to oxidative or hypoxic stress. Unexpectedly, centenarians showed the highest basal levels of p66(shc). Oxidative stress induced p66(shc) in all samples. At variance, hypoxic stress caused p66(shc) reduction only in cells from centenarians. These changes occurred in absence of any modification of p66(shc) promoter methylation pattern. Intriguingly, in cells from centenarians, p66(shc) induction was affected by p53 codon 72 polymorphism. Thus, cells from centenarians present a peculiar regulation of p66(shc), suggesting that its role in mammalian longevity is more complex than previously thought. AU - Pandolfi, S AU - Bonafè, M AU - Di Tella, L AU - Tiberi, L AU - Salvioli, S AU - Monti, D AU - Sorbi, S AU - Franceschi, C PY - 2005/08// UR - http://dx.doi.org/10.1016/j.mad.2005.03.004 ER -