A disease haplotype for advanced nephropathy in type 2 diabetes at the ACE locus.

@article{citeulike:1654030, abstract = {Previous investigations of the ACE gene as a susceptibility factor for diabetic nephropathy have primarily focused on its insertion/deletion (Ins/Del) polymorphism. In a departure from these earlier studies, we used three tagging markers (A-5466C, T-3892C, and Ins/Del) at the ACE locus to test for disease haplotype associations. A case-control study design was used where case subjects were type 2 diabetic patients with advanced diabetic nephropathy, as indicated by the presence of proteinuria or chronic renal failure/end-stage renal disease, while control subjects were normoalbuminuric, despite >6 years of diabetes. None of the individual markers showed significant disease association when considered on their own. However, haplotype analyses revealed a near doubling in the prevalence of the A.T.D risk haplotype in case subjects (0.136) compared with control subjects (0.075) (P = 0.009), thus providing first evidence for a disease haplotype for advanced diabetic nephropathy at the ACE locus.}, address = {Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore.}, author = {Ng, D. P. and Placha, G. and Choo, S. and Chia, K. S. and Warram, J. H. and Krolewski, A. S. }, citeulike-article-id = {1654030}, doi = {http://dx.doi.org/10.2337/db06-0496}, issn = {0012-1797}, journal = {Diabetes}, month = {September}, number = {9}, pages = {2660--2663}, posted-at = {2007-09-14 03:37:21}, priority = {2}, title = {A disease haplotype for advanced nephropathy in type 2 diabetes at the ACE locus.}, url = {http://dx.doi.org/10.2337/db06-0496}, volume = {55}, year = {2006} }

TY - JOUR ID - citeulike:1654030 L3 - citeulike-article-id:1654030 TI - A disease haplotype for advanced nephropathy in type 2 diabetes at the ACE locus. JF - Diabetes VL - 55 IS - 9 SP - 2660 EP - 2663 AD - Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore. SN - 0012-1797 N2 - Previous investigations of the ACE gene as a susceptibility factor for diabetic nephropathy have primarily focused on its insertion/deletion (Ins/Del) polymorphism. In a departure from these earlier studies, we used three tagging markers (A-5466C, T-3892C, and Ins/Del) at the ACE locus to test for disease haplotype associations. A case-control study design was used where case subjects were type 2 diabetic patients with advanced diabetic nephropathy, as indicated by the presence of proteinuria or chronic renal failure/end-stage renal disease, while control subjects were normoalbuminuric, despite >6 years of diabetes. None of the individual markers showed significant disease association when considered on their own. However, haplotype analyses revealed a near doubling in the prevalence of the A.T.D risk haplotype in case subjects (0.136) compared with control subjects (0.075) (P = 0.009), thus providing first evidence for a disease haplotype for advanced diabetic nephropathy at the ACE locus. AU - Ng, DP AU - Placha, G AU - Choo, S AU - Chia, KS AU - Warram, JH AU - Krolewski, AS PY - 2006/09// UR - http://dx.doi.org/10.2337/db06-0496 ER -