An elevated urinary albumin excretion predicts de novo development of renal function impairment in the general population.

@article{citeulike:1510809, abstract = {BACKGROUND: We questioned which factors determine the risk for developing renal function impairment. To that purpose, we studied the incidence of newly diagnosed impaired renal function (GFR <60 mL/min/1.73m2) in the PREVEND cohort (N=8592), which is enriched for the presence of albuminuria, and which was first studied in 1997-1998. Of this cohort, 6894 subjects were studied again four years later. METHODS: Subjects with known renal disease, GFR <60 mL/min, missing GFR values, or sediment abnormalities at the first screening were excluded from the present analysis (N=872). We examined whether albuminuria is associated with the de novo development of an impaired renal function. GFR was 90.3 (SD 16.3) mL/min/1.73m2 at baseline, and 11.6\% of the subjects had an albuminuria of more than 30 mg/day. RESULTS: After a follow-up of four years, 253 subjects (4.2\%) were found to have a GFR <60 mL/min/1.73m2. The subjects with newly diagnosed impaired GFR were older, had a higher blood pressure, serum cholesterol, plasma glucose, and urinary albumin excretion at the first examination, and had a lower GFR to start with than those with a GFR >60 at the second evaluation. Subjects with de novo impaired GFR had a comparable BMI and smoked less frequently compared with subjects with GFR >60. In multivariate analysis, urinary albumin excretion was independently predictive for the risk of developing an impaired GFR (P=0.001). CONCLUSION: Also in the general population, measurement of urinary albumin excretion may prove to be a valuable tool to detect subjects at risk for later development of renal failure, independent of the presence of other cardiovascular risk factors.}, address = {Division of Nephrology, Department of Medicine, University Medical Center Groningen, and Groningen University Institute of Drug Exploration, Groningen, The Netherlands.}, author = {Verhave, J. C. and Gansevoort, R. T. and Hillege, H. L. and Bakker, S. J. and De Zeeuw, D. and de Jong, P. E. and }, citeulike-article-id = {1510809}, doi = {10.1111/j.1523-1755.2004.09205.x}, issn = {0098-6577}, journal = {Kidney Int Suppl}, month = {November}, number = {92}, posted-at = {2007-07-29 03:09:10}, priority = {5}, title = {An elevated urinary albumin excretion predicts de novo development of renal function impairment in the general population.}, url = {http://dx.doi.org/10.1111/j.1523-1755.2004.09205.x}, year = {2004} }

TY - JOUR ID - citeulike:1510809 L3 - citeulike-article-id:1510809 TI - An elevated urinary albumin excretion predicts de novo development of renal function impairment in the general population. JF - Kidney Int Suppl IS - 92 AD - Division of Nephrology, Department of Medicine, University Medical Center Groningen, and Groningen University Institute of Drug Exploration, Groningen, The Netherlands. SN - 0098-6577 N2 - BACKGROUND: We questioned which factors determine the risk for developing renal function impairment. To that purpose, we studied the incidence of newly diagnosed impaired renal function (GFR <60 mL/min/1.73m2) in the PREVEND cohort (N=8592), which is enriched for the presence of albuminuria, and which was first studied in 1997-1998. Of this cohort, 6894 subjects were studied again four years later. METHODS: Subjects with known renal disease, GFR <60 mL/min, missing GFR values, or sediment abnormalities at the first screening were excluded from the present analysis (N=872). We examined whether albuminuria is associated with the de novo development of an impaired renal function. GFR was 90.3 (SD 16.3) mL/min/1.73m2 at baseline, and 11.6% of the subjects had an albuminuria of more than 30 mg/day. RESULTS: After a follow-up of four years, 253 subjects (4.2%) were found to have a GFR <60 mL/min/1.73m2. The subjects with newly diagnosed impaired GFR were older, had a higher blood pressure, serum cholesterol, plasma glucose, and urinary albumin excretion at the first examination, and had a lower GFR to start with than those with a GFR >60 at the second evaluation. Subjects with de novo impaired GFR had a comparable BMI and smoked less frequently compared with subjects with GFR >60. In multivariate analysis, urinary albumin excretion was independently predictive for the risk of developing an impaired GFR (P=0.001). CONCLUSION: Also in the general population, measurement of urinary albumin excretion may prove to be a valuable tool to detect subjects at risk for later development of renal failure, independent of the presence of other cardiovascular risk factors. AU - Verhave, JC AU - Gansevoort, RT AU - Hillege, HL AU - Bakker, SJ AU - De Zeeuw, D AU - de Jong, PE PY - 2004/11// UR - http://dx.doi.org/10.1111/j.1523-1755.2004.09205.x ER -