Introduction and overview. Statistical methods in genetic epidemiology.

by: RC Elston

Stat Methods Med Res, Vol. 9, No. 6. (December 2000), pp. 527-541.

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Abstract

Common terms used in genetics with multiple meanings are explained and a brief overview given of the four major areas of genetic epidemiology--the study of familial aggregation, segregation, cosegregation and association. Familial aggregation measures the potential for a trait to have a genetic aetiology. Segregation analysis uncovers single gene segregation. Cosegregation with genetic markers gives rise to linkage, which is used to locate trait genes on the genome. Association analysis is used for fine mapping, but rests on the assumption that linkage disequilibrium exists.

@article{citeulike:1439694, abstract = {Common terms used in genetics with multiple meanings are explained and a brief overview given of the four major areas of genetic epidemiology--the study of familial aggregation, segregation, cosegregation and association. Familial aggregation measures the potential for a trait to have a genetic aetiology. Segregation analysis uncovers single gene segregation. Cosegregation with genetic markers gives rise to linkage, which is used to locate trait genes on the genome. Association analysis is used for fine mapping, but rests on the assumption that linkage disequilibrium exists.}, address = {Department of Epidemiology and Biostatistics, Rammelkamp Center for Education and Research, Case Western Reserve University, Cleveland, Ohio 44109-1998, USA. rce@darwin.cwru.edu}, author = {Elston, R. C. }, citeulike-article-id = {1439694}, issn = {0962-2802}, journal = {Stat Methods Med Res}, keywords = {genetics, heritability}, month = {December}, number = {6}, pages = {527--541}, posted-at = {2007-07-06 17:05:59}, priority = {2}, title = {Introduction and overview. Statistical methods in genetic epidemiology.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/11308069}, volume = {9}, year = {2000} }

RIS record

TY - JOUR ID - citeulike:1439694 L3 - citeulike-article-id:1439694 TI - Introduction and overview. Statistical methods in genetic epidemiology. JF - Stat Methods Med Res VL - 9 IS - 6 SP - 527 EP - 541 AD - Department of Epidemiology and Biostatistics, Rammelkamp Center for Education and Research, Case Western Reserve University, Cleveland, Ohio 44109-1998, USA. rce@darwin.cwru.edu SN - 0962-2802 N2 - Common terms used in genetics with multiple meanings are explained and a brief overview given of the four major areas of genetic epidemiology--the study of familial aggregation, segregation, cosegregation and association. Familial aggregation measures the potential for a trait to have a genetic aetiology. Segregation analysis uncovers single gene segregation. Cosegregation with genetic markers gives rise to linkage, which is used to locate trait genes on the genome. Association analysis is used for fine mapping, but rests on the assumption that linkage disequilibrium exists. KW - genetics KW - heritability AU - Elston, RC PY - 2000/12// UR - http://view.ncbi.nlm.nih.gov/pubmed/11308069 ER -

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