Key concepts in genetic epidemiology

by: Paul R Burton, Martin D Tobin, John L Hopper

The Lancet, Vol. 366, No. 9489., pp. 941-951.

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Abstract

Summary This article is the first in a series of seven that will provide an overview of central concepts and topical issues in modern genetic epidemiology. In this article, we provide an overall framework for investigating the role of familial factors, especially genetic determinants, in the causation of complex diseases such as diabetes. The discrete steps of the framework to be outlined integrate the biological science underlying modern genetics and the population science underpinning mainstream epidemiology. In keeping with the broad readership of The Lancet and the diverse background of today's genetic epidemiologists, we provide introductory sections to equip readers with basic concepts and vocabulary. We anticipate that, depending on their professional background and specialist knowledge, some readers will wish to skip some of this article.

@article{citeulike:1408549, abstract = {Summary This article is the first in a series of seven that will provide an overview of central concepts and topical issues in modern genetic epidemiology. In this article, we provide an overall framework for investigating the role of familial factors, especially genetic determinants, in the causation of complex diseases such as diabetes. The discrete steps of the framework to be outlined integrate the biological science underlying modern genetics and the population science underpinning mainstream epidemiology. In keeping with the broad readership of The Lancet and the diverse background of today's genetic epidemiologists, we provide introductory sections to equip readers with basic concepts and vocabulary. We anticipate that, depending on their professional background and specialist knowledge, some readers will wish to skip some of this article.}, author = {Burton, Paul R. and Tobin, Martin D. and Hopper, John L. }, citeulike-article-id = {1408549}, journal = {The Lancet}, keywords = {genetics, statistics}, number = {9489}, pages = {941--951}, posted-at = {2007-06-24 05:05:41}, priority = {2}, title = {Key concepts in genetic epidemiology}, url = {http://www.sciencedirect.com/science/article/B6T1B-4H2KVVS-13/2/d9653f276900b10f2f6baecb60475b6f}, volume = {366} }

RIS record

TY - JOUR ID - citeulike:1408549 L3 - citeulike-article-id:1408549 TI - Key concepts in genetic epidemiology JF - The Lancet VL - 366 IS - 9489 SP - 941 EP - 951 N2 - Summary This article is the first in a series of seven that will provide an overview of central concepts and topical issues in modern genetic epidemiology. In this article, we provide an overall framework for investigating the role of familial factors, especially genetic determinants, in the causation of complex diseases such as diabetes. The discrete steps of the framework to be outlined integrate the biological science underlying modern genetics and the population science underpinning mainstream epidemiology. In keeping with the broad readership of The Lancet and the diverse background of today's genetic epidemiologists, we provide introductory sections to equip readers with basic concepts and vocabulary. We anticipate that, depending on their professional background and specialist knowledge, some readers will wish to skip some of this article. KW - genetics KW - statistics AU - Burton, Paul AU - Tobin, Martin AU - Hopper, John UR - http://www.sciencedirect.com/science/article/B6T1B-4H2KVVS-13/2/d9653f276900b10f2f6baecb60475b6f ER -

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