AR, apoE, and cognitive function

@article{citeulike:2919753, abstract = {Reduced androgen levels in aged men and women might be risk factors for age-related cognitive decline and Alzheimer's disease (AD). Ongoing clinical trials are designed to evaluate the potential benefit of estrogen in women and of testosterone in men. In this review, we discuss the potential beneficial effects of androgens and androgen receptors (ARs) in males and females. In addition, we discuss the hypothesis that AR interacts with apolipoprotein (apoE)4, encoded by [epsilon]4 and a risk factor for age-related cognitive decline and AD, and the potential consequences of this interaction.}, author = {Raber, Jacob }, booktitle = {Androgens in Health and Disease: new insights into roles and mechanisms of action, 12th Annual Society for Behavioral Neuroendocrinology Meeting}, citeulike-article-id = {2919753}, doi = {http://dx.doi.org/10.1016/j.yhbeh.2008.02.012}, journal = {Hormones and Behavior}, keywords = {ad, androgens, apoe, cognition, general, polymorphism, review}, month = {May}, number = {5}, pages = {706--715}, posted-at = {2008-06-23 21:53:49}, priority = {4}, title = {AR, apoE, and cognitive function}, url = {http://dx.doi.org/10.1016/j.yhbeh.2008.02.012}, volume = {53}, year = {2008} }

TY - JOUR ID - citeulike:2919753 L3 - citeulike-article-id:2919753 TI - AR, apoE, and cognitive function T2 - Androgens in Health and Disease: new insights into roles and mechanisms of action, 12th Annual Society for Behavioral Neuroendocrinology Meeting JF - Hormones and Behavior VL - 53 IS - 5 SP - 706 EP - 715 N2 - Reduced androgen levels in aged men and women might be risk factors for age-related cognitive decline and Alzheimer's disease (AD). Ongoing clinical trials are designed to evaluate the potential benefit of estrogen in women and of testosterone in men. In this review, we discuss the potential beneficial effects of androgens and androgen receptors (ARs) in males and females. In addition, we discuss the hypothesis that AR interacts with apolipoprotein (apoE)4, encoded by [epsilon]4 and a risk factor for age-related cognitive decline and AD, and the potential consequences of this interaction. KW - ad KW - androgens KW - apoe KW - cognition KW - general KW - polymorphism KW - review AU - Raber, Jacob PY - 2008/05// UR - http://dx.doi.org/10.1016/j.yhbeh.2008.02.012 ER -