Rostral anterior cingulate volume predicts treatment response to cognitive-behavioural therapy for posttraumatic stress disorder.

@article{citeulike:2630079, abstract = {OBJECTIVE: To index the extent to which treatment response in posttraumatic stress disorder (PTSD) is predicted by rostral anterior cingulate cortex (rACC) volume. METHOD: We used structural magnetic resonance imaging in a 1.5 T scanner to examine subjects with PTSD (n = 13), traumatized control subjects (n = 13) and nontraumatized control subjects (n = 13). Subjects with PTSD then participated in 8 sessions of cognitive-behavioural therapy, after which we reassessed them for PTSD. RESULTS: According to voxel-based morphometry, treatment responders had larger rACC volume than nonresponders. Further, symptom reduction was associated with larger rACC volume. CONCLUSION: Consistent with evidence for the neural bases of extinction learning, PTSD patients with larger rACC volume may be better able to regulate fear during cognitive-behavioural therapy and thus achieve greater treatment gains.}, address = {Brain Dynamics Centre, Westmead Hospital, Sydney, Australia. r.bryant@unsw.edu.au}, author = {Bryant, R. A. and Felmingham, K. and Whitford, T. J. and Kemp, A. and Hughes, G. and Peduto, A. and Williams, L. M. }, citeulike-article-id = {2630079}, issn = {1180-4882}, journal = {Journal of psychiatry \& neuroscience : JPN}, keywords = {anterior\_cingulate, imaging, mri, stress}, month = {March}, number = {2}, pages = {142--146}, posted-at = {2008-04-04 16:53:34}, priority = {2}, title = {Rostral anterior cingulate volume predicts treatment response to cognitive-behavioural therapy for posttraumatic stress disorder.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/18330460}, volume = {33}, year = {2008} }

TY - JOUR ID - citeulike:2630079 L3 - citeulike-article-id:2630079 TI - Rostral anterior cingulate volume predicts treatment response to cognitive-behavioural therapy for posttraumatic stress disorder. JF - Journal of psychiatry & neuroscience : JPN VL - 33 IS - 2 SP - 142 EP - 146 AD - Brain Dynamics Centre, Westmead Hospital, Sydney, Australia. r.bryant@unsw.edu.au SN - 1180-4882 N2 - OBJECTIVE: To index the extent to which treatment response in posttraumatic stress disorder (PTSD) is predicted by rostral anterior cingulate cortex (rACC) volume. METHOD: We used structural magnetic resonance imaging in a 1.5 T scanner to examine subjects with PTSD (n = 13), traumatized control subjects (n = 13) and nontraumatized control subjects (n = 13). Subjects with PTSD then participated in 8 sessions of cognitive-behavioural therapy, after which we reassessed them for PTSD. RESULTS: According to voxel-based morphometry, treatment responders had larger rACC volume than nonresponders. Further, symptom reduction was associated with larger rACC volume. CONCLUSION: Consistent with evidence for the neural bases of extinction learning, PTSD patients with larger rACC volume may be better able to regulate fear during cognitive-behavioural therapy and thus achieve greater treatment gains. KW - anterior_cingulate KW - imaging KW - mri KW - stress AU - Bryant, RA AU - Felmingham, K AU - Whitford, TJ AU - Kemp, A AU - Hughes, G AU - Peduto, A AU - Williams, LM PY - 2008/03// UR - http://view.ncbi.nlm.nih.gov/pubmed/18330460 ER -