Conformational diversity and protein evolution - a 60-year-old hypothesis revisited

@article{citeulike:2557193, abstract = {Complex organisms have evolved from a limited number of primordial genes and proteins. However, the mechanisms by which the earliest proteins evolved and then served as the origin for the present diversity of protein function are unknown. Here, we outline a hypothesis based on the 'new view' of proteins whereby one sequence can adopt multiple structures and functions. We suggest that such conformational diversity could increase the functional diversity of a limited repertoire of sequences and, thereby, facilitate the evolution of new proteins and functions from old ones.}, author = {James, L. C. }, citeulike-article-id = {2557193}, month = {July}, pages = {361--368}, posted-at = {2008-03-19 06:06:18}, priority = {2}, title = {Conformational diversity and protein evolution - a 60-year-old hypothesis revisited}, url = {http://www.ingentaconnect.com/content/els/09680004/2003/00000028/00000007/art00135} }

TY - JOUR ID - citeulike:2557193 L3 - citeulike-article-id:2557193 TI - Conformational diversity and protein evolution - a 60-year-old hypothesis revisited SP - 361 EP - 368 N2 - Complex organisms have evolved from a limited number of primordial genes and proteins. However, the mechanisms by which the earliest proteins evolved and then served as the origin for the present diversity of protein function are unknown. Here, we outline a hypothesis based on the 'new view' of proteins whereby one sequence can adopt multiple structures and functions. We suggest that such conformational diversity could increase the functional diversity of a limited repertoire of sequences and, thereby, facilitate the evolution of new proteins and functions from old ones. AU - James, LC UR - http://www.ingentaconnect.com/content/els/09680004/2003/00000028/00000007/art00135 ER -