Prefrontal Cortex Function in the Representation of Temporally Complex Events

@article{citeulike:2647306, abstract = {The frontal cortex and inferior temporal cortex are strongly functionally interconnected. Previous experiments on prefrontal function in monkeys have shown that a disconnection of prefrontal cortex from inferior temporal cortex impairs a variety of complex visual learning tasks but leaves simple concurrent objectreward association learning intact. We investigated the possibility that temporal components of visual learning tasks determine the sensitivity of those tasks to prefrontaltemporal disconnection by adding specific temporal components to the concurrent objectreward association learning task. Monkeys with crossed unilateral lesions of prefrontal cortex and inferior temporal cortex were impaired compared with unoperated controls at associating two-item sequences of visual objects with reward. The impairment was specific to the learning of visual sequences, because disconnection was without effect on objectreward association learning for an equivalent delayed reward. This result was replicated in monkeys with transection of the uncinate fascicle, thus determining the anatomical specificity of the dissociation. Previous behavioral results suggest that monkeys represent the two-item serial compound stimuli in a configural manner, similar to the way monkeys represent simultaneously presented compound stimuli. The representation of simultaneously presented configural stimuli depends on the perirhinal cortex. The present experiments show that the representation of serially presented compound stimuli depends on the interaction of prefrontal cortex and inferior temporal cortex. We suggest that prefrontaltemporal disconnection impairs a wide variety of learning tasks because in those tasks monkeys lay down similar temporally complex representations. 10.1523/JNEUROSCI.0633-08.2008}, author = {Browning, Philip G. and Gaffan, David }, citeulike-article-id = {2647306}, doi = {10.1523/JNEUROSCI.0633-08.2008}, journal = {J. Neurosci.}, keywords = {brian, jessica, nichola, prefrontal, temporal}, month = {April}, number = {15}, pages = {3934--3940}, posted-at = {2008-04-16 16:24:50}, priority = {2}, title = {Prefrontal Cortex Function in the Representation of Temporally Complex Events}, url = {http://dx.doi.org/10.1523/JNEUROSCI.0633-08.2008}, volume = {28}, year = {2008} }

TY - JOUR ID - citeulike:2647306 L3 - citeulike-article-id:2647306 TI - Prefrontal Cortex Function in the Representation of Temporally Complex Events JF - J. Neurosci. VL - 28 IS - 15 SP - 3934 EP - 3940 N2 - The frontal cortex and inferior temporal cortex are strongly functionally interconnected. Previous experiments on prefrontal function in monkeys have shown that a disconnection of prefrontal cortex from inferior temporal cortex impairs a variety of complex visual learning tasks but leaves simple concurrent objectreward association learning intact. We investigated the possibility that temporal components of visual learning tasks determine the sensitivity of those tasks to prefrontaltemporal disconnection by adding specific temporal components to the concurrent objectreward association learning task. Monkeys with crossed unilateral lesions of prefrontal cortex and inferior temporal cortex were impaired compared with unoperated controls at associating two-item sequences of visual objects with reward. The impairment was specific to the learning of visual sequences, because disconnection was without effect on objectreward association learning for an equivalent delayed reward. This result was replicated in monkeys with transection of the uncinate fascicle, thus determining the anatomical specificity of the dissociation. Previous behavioral results suggest that monkeys represent the two-item serial compound stimuli in a configural manner, similar to the way monkeys represent simultaneously presented compound stimuli. The representation of simultaneously presented configural stimuli depends on the perirhinal cortex. The present experiments show that the representation of serially presented compound stimuli depends on the interaction of prefrontal cortex and inferior temporal cortex. We suggest that prefrontaltemporal disconnection impairs a wide variety of learning tasks because in those tasks monkeys lay down similar temporally complex representations. 10.1523/JNEUROSCI.0633-08.2008 KW - brian KW - jessica KW - nichola KW - prefrontal KW - temporal AU - Browning, Philip AU - Gaffan, David PY - 2008/04/09/ UR - http://dx.doi.org/10.1523/JNEUROSCI.0633-08.2008 ER -