Sensory suppression during feeding.

@article{citeulike:1340260, abstract = {Feeding is essential for survival, whereas withdrawal and escape reactions are fundamentally protective. These critical behaviors can compete for an animal's resources when an acutely painful stimulus affects the animal during feeding. One solution to the feeding-withdrawal conflict is to optimize feeding by suppressing pain. We examined whether rats continue to feed when challenged with a painful stimulus. During feeding, motor withdrawal responses to noxious paw heat either did not occur or were greatly delayed. To investigate the neural basis of sensory suppression accompanying feeding, we recorded from brainstem pain-modulatory neurons involved in the descending control of pain transmission. During feeding, pain-facilitatory ON cells were inhibited and pain-inhibitory OFF cells were excited. When a nonpainful somatosensory stimulus preactivated ON cells and preinhibited OFF cells, rats interrupted eating to react to painful stimuli. Inactivation of the brainstem region containing ON and OFF cells also blocked pain suppression during eating, demonstrating that brainstem pain-modulatory neurons suppress motor reactions to external stimulation during homeostatic behaviors.}, address = {Department of Neurobiology, University of Chicago, IL 60637, USA.}, author = {Foo, H. and Mason, P. }, citeulike-article-id = {1340260}, comment = {This is quite relevant to my lick suppression paradigm}, doi = {10.1073/pnas.0506226102}, issn = {0027-8424}, journal = {Proc Natl Acad Sci U S A}, keywords = {food, pain, suppression}, month = {November}, number = {46}, pages = {16865--16869}, posted-at = {2007-05-29 06:50:07}, priority = {2}, title = {Sensory suppression during feeding.}, url = {http://dx.doi.org/10.1073/pnas.0506226102}, volume = {102}, year = {2005} }

TY - JOUR ID - citeulike:1340260 L3 - citeulike-article-id:1340260 TI - Sensory suppression during feeding. JF - Proc Natl Acad Sci U S A VL - 102 IS - 46 SP - 16865 EP - 16869 AD - Department of Neurobiology, University of Chicago, IL 60637, USA. SN - 0027-8424 N2 - Feeding is essential for survival, whereas withdrawal and escape reactions are fundamentally protective. These critical behaviors can compete for an animal's resources when an acutely painful stimulus affects the animal during feeding. One solution to the feeding-withdrawal conflict is to optimize feeding by suppressing pain. We examined whether rats continue to feed when challenged with a painful stimulus. During feeding, motor withdrawal responses to noxious paw heat either did not occur or were greatly delayed. To investigate the neural basis of sensory suppression accompanying feeding, we recorded from brainstem pain-modulatory neurons involved in the descending control of pain transmission. During feeding, pain-facilitatory ON cells were inhibited and pain-inhibitory OFF cells were excited. When a nonpainful somatosensory stimulus preactivated ON cells and preinhibited OFF cells, rats interrupted eating to react to painful stimuli. Inactivation of the brainstem region containing ON and OFF cells also blocked pain suppression during eating, demonstrating that brainstem pain-modulatory neurons suppress motor reactions to external stimulation during homeostatic behaviors. KW - food KW - pain KW - suppression N1 - This is quite relevant to my lick suppression paradigm AU - Foo, H AU - Mason, P PY - 2005/11/15/ UR - http://dx.doi.org/10.1073/pnas.0506226102 ER -