Neurocognitive mechanisms of anxiety: an integrative account.

@article{citeulike:1373867, abstract = {Anxiety can be hugely disruptive to everyday life. Anxious individuals show increased attentional capture by potential signs of danger, and interpret expressions, comments and events in a negative manner. These cognitive biases have been widely explored in human anxiety research. By contrast, animal models have focused upon the mechanisms underlying acquisition and extinction of conditioned fear, guiding exposure-based therapies for anxiety disorders. Recent neuroimaging studies of conditioned fear, attention to threat and interpretation of emotionally ambiguous stimuli indicate common amygdala-prefrontal circuitry underlying these processes, and suggest that the balance of activity within this circuitry is altered in anxiety, creating a bias towards threat-related responses. This provides a focus for future translational research, and targeted pharmacological and cognitive interventions.}, address = {Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK; Medical Research Council Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge, CB2 2EF, UK.}, author = {Bishop, Sonia J J. }, citeulike-article-id = {1373867}, doi = {10.1016/j.tics.2007.05.008}, issn = {1364-6613}, journal = {Trends Cogn Sci}, keywords = {anxiety, neuroimaging, review}, month = {June}, posted-at = {2007-06-09 05:35:46}, priority = {4}, title = {Neurocognitive mechanisms of anxiety: an integrative account.}, url = {http://dx.doi.org/10.1016/j.tics.2007.05.008}, year = {2007} }

TY - JOUR ID - citeulike:1373867 L3 - citeulike-article-id:1373867 TI - Neurocognitive mechanisms of anxiety: an integrative account. JF - Trends Cogn Sci AD - Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK; Medical Research Council Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge, CB2 2EF, UK. SN - 1364-6613 N2 - Anxiety can be hugely disruptive to everyday life. Anxious individuals show increased attentional capture by potential signs of danger, and interpret expressions, comments and events in a negative manner. These cognitive biases have been widely explored in human anxiety research. By contrast, animal models have focused upon the mechanisms underlying acquisition and extinction of conditioned fear, guiding exposure-based therapies for anxiety disorders. Recent neuroimaging studies of conditioned fear, attention to threat and interpretation of emotionally ambiguous stimuli indicate common amygdala-prefrontal circuitry underlying these processes, and suggest that the balance of activity within this circuitry is altered in anxiety, creating a bias towards threat-related responses. This provides a focus for future translational research, and targeted pharmacological and cognitive interventions. KW - anxiety KW - neuroimaging KW - review AU - Bishop, Sonia J PY - 2007/06/04/ UR - http://dx.doi.org/10.1016/j.tics.2007.05.008 ER -