State anxiety modulation of the amygdala response to unattended threat-related stimuli.

@article{citeulike:1287825, abstract = {Findings from fear-conditioning studies in rats and functional neuroimaging with human volunteers have led to the suggestion that the amygdala is involved in the preattentive detection of threat-related stimuli. However, some neuroimaging findings point to attentional modulation of the amygdala response. The clinical-cognitive literature suggests that the extent to which the processing of threat-related stimuli is modulated by attention is crucially dependent on participants' anxiety levels. Here, we conducted a functional magnetic resonance imaging study with 27 healthy volunteers to examine whether amygdala responsivity to unattended threat-related stimuli varies with individual differences in state anxiety. Pairs of houses and faces (both fearful or neutral in expression) were presented, and participants attended to either the faces or the houses and matched these stimuli on identity. "Low-anxious" participants showed a reduced amygdala response to unattended versus attended fearful faces, but "high-anxious" participants showed no such reduction, having an increased amygdala response to fearful versus neutral faces regardless of attentional focus. These findings suggest that anxiety may interact with attentional focus to determine the magnitude of the amygdala response to threat-related stimuli.}, address = {Medical Research Council Cognition and Brain Sciences Unit, Cambridge CB2 2EF, United Kingdom. sonia.bishop@mrc-cbu.cam.ac.uk}, author = {Bishop, S. J. and Duncan, J. and Lawrence, A. D. }, citeulike-article-id = {1287825}, comment = {27名の健常者を対象に、unattendedなfear faceに対するamygdalaの活動と状態不安の関係をfMRIを使って調べた。課題はhouse画像もしくはface画像の異同判断。どちらを判断するかはcueで知らせる。低状態不安者はunattendedなfear faceに対してはamygdalaの活動が低いが、高状態不安者ではattended,unattendedどちらのfear faceでもamygdalaの活動が高い。attentional focusと不安が相互作用し、amygdalaの活動に影響している？}, doi = {10.1523/JNEUROSCI.2550-04.2004}, issn = {1529-2401}, journal = {J Neurosci}, keywords = {amygdala, anxiety, emotion, expression, face, fmri, state-anxiety}, month = {November}, number = {46}, pages = {10364--10368}, posted-at = {2007-05-12 07:27:16}, priority = {0}, title = {State anxiety modulation of the amygdala response to unattended threat-related stimuli.}, url = {http://dx.doi.org/10.1523/JNEUROSCI.2550-04.2004}, volume = {24}, year = {2004} }

TY - JOUR ID - citeulike:1287825 L3 - citeulike-article-id:1287825 TI - State anxiety modulation of the amygdala response to unattended threat-related stimuli. JF - J Neurosci VL - 24 IS - 46 SP - 10364 EP - 10368 AD - Medical Research Council Cognition and Brain Sciences Unit, Cambridge CB2 2EF, United Kingdom. sonia.bishop@mrc-cbu.cam.ac.uk SN - 1529-2401 N2 - Findings from fear-conditioning studies in rats and functional neuroimaging with human volunteers have led to the suggestion that the amygdala is involved in the preattentive detection of threat-related stimuli. However, some neuroimaging findings point to attentional modulation of the amygdala response. The clinical-cognitive literature suggests that the extent to which the processing of threat-related stimuli is modulated by attention is crucially dependent on participants' anxiety levels. Here, we conducted a functional magnetic resonance imaging study with 27 healthy volunteers to examine whether amygdala responsivity to unattended threat-related stimuli varies with individual differences in state anxiety. Pairs of houses and faces (both fearful or neutral in expression) were presented, and participants attended to either the faces or the houses and matched these stimuli on identity. "Low-anxious" participants showed a reduced amygdala response to unattended versus attended fearful faces, but "high-anxious" participants showed no such reduction, having an increased amygdala response to fearful versus neutral faces regardless of attentional focus. These findings suggest that anxiety may interact with attentional focus to determine the magnitude of the amygdala response to threat-related stimuli. KW - amygdala KW - anxiety KW - emotion KW - expression KW - face KW - fmri KW - state-anxiety N1 - 27名の健常者を対象に、unattendedなfear faceに対するamygdalaの活動と状態不安の関係をfMRIを使って調べた。課題はhouse画像もしくはface画像の異同判断。どちらを判断するかはcueで知らせる。低状態不安者はunattendedなfear faceに対してはamygdalaの活動が低いが、高状態不安者ではattended,unattendedどちらのfear faceでもamygdalaの活動が高い。attentional focusと不安が相互作用し、amygdalaの活動に影響している？ AU - Bishop, SJ AU - Duncan, J AU - Lawrence, AD PY - 2004/11/17/ UR - http://dx.doi.org/10.1523/JNEUROSCI.2550-04.2004 ER -