Quantitative analysis of serum free light chains. A new marker for the diagnostic evaluation of primary systemic amyloidosis.

@article{citeulike:2633038, abstract = {Primary systemic amyloidosis is a plasma cell dyscrasia characterized by the accumulation of excess free immunoglobulin light chains (FLCs) as amyloid. One of the diagnostic features of amyloidosis is the presence of circulating monoclonal FLCs in the serum and urine of the patients. The FLC usually is present in small amounts, and immunofixation is required for detection. A nephelometric method for quantitating FLCs in serum has been described using antibodies that recognize only FLC not bound to heavy chain. We describe a retrospective study using this quantitative FLC method for assessing monoclonal FLCs in 95 patients with amyloidosis. The sensitivity of nephelometric serum FLC measurements is particularly useful in patients with negative immunofixation results for serum, urine, or both. In addition, the FLC assay can be used for follow-up of patients with amyloidosis who have undergone stem cell transplantation.}, address = {Division of Clinical Biochemistry and Immunology, University of Birmingham, Birmingham, England.}, author = {Abraham, R. S. and Katzmann, J. A. and Clark, R. J. and Bradwell, A. R. and Kyle, R. A. and Gertz, M. A. }, citeulike-article-id = {2633038}, doi = {http://dx.doi.org/10.1309/LYWM-47K2-L8XY-FFB3}, issn = {0002-9173}, journal = {American journal of clinical pathology}, keywords = {amyloidosis, flc}, month = {February}, number = {2}, pages = {274--278}, posted-at = {2008-04-05 17:51:35}, priority = {2}, title = {Quantitative analysis of serum free light chains. A new marker for the diagnostic evaluation of primary systemic amyloidosis.}, url = {http://dx.doi.org/10.1309/LYWM-47K2-L8XY-FFB3}, volume = {119}, year = {2003} }

TY - JOUR ID - citeulike:2633038 L3 - citeulike-article-id:2633038 TI - Quantitative analysis of serum free light chains. A new marker for the diagnostic evaluation of primary systemic amyloidosis. JF - American journal of clinical pathology VL - 119 IS - 2 SP - 274 EP - 278 AD - Division of Clinical Biochemistry and Immunology, University of Birmingham, Birmingham, England. SN - 0002-9173 N2 - Primary systemic amyloidosis is a plasma cell dyscrasia characterized by the accumulation of excess free immunoglobulin light chains (FLCs) as amyloid. One of the diagnostic features of amyloidosis is the presence of circulating monoclonal FLCs in the serum and urine of the patients. The FLC usually is present in small amounts, and immunofixation is required for detection. A nephelometric method for quantitating FLCs in serum has been described using antibodies that recognize only FLC not bound to heavy chain. We describe a retrospective study using this quantitative FLC method for assessing monoclonal FLCs in 95 patients with amyloidosis. The sensitivity of nephelometric serum FLC measurements is particularly useful in patients with negative immunofixation results for serum, urine, or both. In addition, the FLC assay can be used for follow-up of patients with amyloidosis who have undergone stem cell transplantation. KW - amyloidosis KW - flc AU - Abraham, RS AU - Katzmann, JA AU - Clark, RJ AU - Bradwell, AR AU - Kyle, RA AU - Gertz, MA PY - 2003/02// UR - http://dx.doi.org/10.1309/LYWM-47K2-L8XY-FFB3 ER -