The Wiskott-Aldrich syndrome protein: forging the link between actin and cell activation.

@article{citeulike:2949839, abstract = {The Wiskott-Aldrich syndrome protein (WASp) has emerged as a central player in the regulation of actin remodeling in T cells. The unique domain structure of WASp and other WASp family members enables these proteins to associate with a myriad of signaling effectors and to thereby regulate the coupling of T cell antigen receptor (TCR) engagement to both cytoskeletal rearrangement and transcriptional activation. This review focuses on these biochemical properties of WASp and also on the mechanisms whereby WASp interactions with its cognate ligands influence T cell activation. Because of its capacity to shift intracellular location and thereby dictate both the timing and the spatial distribution of actin polymerization following cell stimulation, WASp is well positioned to play major regulatory roles in directing a wide range of cellular processes and signaling pathways. Further dissection of the functional and biochemical properties of WASp therefore represents a promising avenue towards defining the molecular mechanisms that convey TCR stimulatory signals to the actin cytoskeleton and integrate cytoskeletal and other signaling systems so as to evoke a biological response.}, address = {Department of Medicine, Immunology and Medical Genetics and Microbiology, University of Toronto, Samuel Ontario, Canada.}, author = {Badour, K. and Zhang, J. and Siminovitch, K. A. }, citeulike-article-id = {2949839}, issn = {0105-2896}, journal = {Immunological reviews}, keywords = {was}, month = {April}, pages = {98--112}, posted-at = {2008-07-02 04:32:42}, priority = {2}, title = {The Wiskott-Aldrich syndrome protein: forging the link between actin and cell activation.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/12670398}, volume = {192}, year = {2003} }

TY - JOUR ID - citeulike:2949839 L3 - citeulike-article-id:2949839 TI - The Wiskott-Aldrich syndrome protein: forging the link between actin and cell activation. JF - Immunological reviews VL - 192 SP - 98 EP - 112 AD - Department of Medicine, Immunology and Medical Genetics and Microbiology, University of Toronto, Samuel Ontario, Canada. SN - 0105-2896 N2 - The Wiskott-Aldrich syndrome protein (WASp) has emerged as a central player in the regulation of actin remodeling in T cells. The unique domain structure of WASp and other WASp family members enables these proteins to associate with a myriad of signaling effectors and to thereby regulate the coupling of T cell antigen receptor (TCR) engagement to both cytoskeletal rearrangement and transcriptional activation. This review focuses on these biochemical properties of WASp and also on the mechanisms whereby WASp interactions with its cognate ligands influence T cell activation. Because of its capacity to shift intracellular location and thereby dictate both the timing and the spatial distribution of actin polymerization following cell stimulation, WASp is well positioned to play major regulatory roles in directing a wide range of cellular processes and signaling pathways. Further dissection of the functional and biochemical properties of WASp therefore represents a promising avenue towards defining the molecular mechanisms that convey TCR stimulatory signals to the actin cytoskeleton and integrate cytoskeletal and other signaling systems so as to evoke a biological response. KW - was AU - Badour, K AU - Zhang, J AU - Siminovitch, KA PY - 2003/04// UR - http://view.ncbi.nlm.nih.gov/pubmed/12670398 ER -