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Lethality and centrality in protein networks

by: H Jeong, SP Mason, AL Barabasi, ZN Oltvai

Nature, Vol. 411, No. 6833. (3 May 2001), pp. 41-42.

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abstraction alignmentgraph allpurpose analysis approach approximations assess assessment associations attachment attributes autocorrelation belief betweenness biological boosting building carcinoma cautious cc cell cellular centralityrandom chain classescomplex classifciation classificaiton classification classificationiterative clique clustering coefficient coefficientssamplingspurious coevolution collective color-coding combine communities communitiesrelated community comparative complex confidence conserved construction context-sensititive crf cygd data databases ddi decision degree degree-basedstructural denoising denosing detection diffusion disassortative diseases diverse domain domainppi domains energy entropy essential evaluation evolution expander experimental exponential expression extraction factor feature forest fp function functional functionppi fusion fusionmultigraph gene generalized generator genes genetic genome genomic geomic global go graph graphs graphsdefinition group guildscommunitypcanetwork hepatocellular heterogeneity hierarchical hms-pci ht human ig index inference inferencesupervised information integrated integration interaction interactionpreferential interactions interactionsppi interconnectednesstopological intersection kdd kernels knowledgeppi labeling large-scale latent latent-variable learning learningprobabilistic link link-based link-mining link-prediction local localization lock-and-key logistic logit lr machine markov mass matrices maximization mcmc measure mechanisms metabolic methods metric minimization mining mixing mln model modeling modelling modelshomophily modularity modularitycommunity module motif motifs motifsgeometric mrf multiple muticlass negation netowrk networ network network-based networkinfer networks networksquasibipartitesquasicliques networktopologyclustering noisy noisyor object of one-class ontology organisms outcome overlap overlapping paradox pathway pathways pattern percolationppi phylogenetic physical ppi ppidisease ppinetwork ppitopology prediction principle prm probabilistc probabilistic propagation propagationfree-energy protein protein-protein proteomics r50 random reduction regression regressions regulatory relational relationalmodels relaxation reliability review rmn roc rosetta sampling samplingnetwork scale-free search seedy semantic semi-markov sharpeninggraph signal signaling signalling similarity similaritygo singal-transduction small-world social source spectrometry srl statistical stem stickiness stone strategyconnectivityaging string structural structure structurenetworks study subgraphs sum-product supervised svdd svms synchronization tap techniques the theorycomplex topological topology topologysignature topologyweighted transduction transferred treedistance trw-s unsupervised walks weighted weightsprotein yeast