Progress in Modeling of Protein Structures and Interactions

by: Ora Schueler-Furman, Chu Wang, Phil Bradley, Kira Misura, David Baker

Science, Vol. 310, No. 5748. (28 October 2005), pp. 638-642.

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Abstract

The prediction of the structures and interactions of biological macromolecules at the atomic level and the design of new structures and interactions are critical tests of our understanding of the interatomic interactions that underlie molecular biology. Equally important, the capability to accurately predict and design macromolecular structures and interactions would streamline the interpretation of genome sequence information and allow the creation of macromolecules with new and useful functions. This review summarizes recent progress in modeling that suggests that we are entering an era in which high-resolution prediction and design will make increasingly important contributions to biology and medicine.

@article{citeulike:368203, abstract = {The prediction of the structures and interactions of biological macromolecules at the atomic level and the design of new structures and interactions are critical tests of our understanding of the interatomic interactions that underlie molecular biology. Equally important, the capability to accurately predict and design macromolecular structures and interactions would streamline the interpretation of genome sequence information and allow the creation of macromolecules with new and useful functions. This review summarizes recent progress in modeling that suggests that we are entering an era in which high-resolution prediction and design will make increasingly important contributions to biology and medicine.}, author = {Schueler-Furman, Ora and Wang, Chu and Bradley, Phil and Misura, Kira and Baker, David }, citeulike-article-id = {368203}, doi = {http://dx.doi.org/10.1126/science.1112160}, journal = {Science}, keywords = {pfc3, review, structural\_modeling}, month = {October}, number = {5748}, pages = {638--642}, posted-at = {2008-04-16 15:43:42}, priority = {2}, title = {Progress in Modeling of Protein Structures and Interactions}, url = {http://dx.doi.org/10.1126/science.1112160}, volume = {310}, year = {2005} }

RIS record

TY - JOUR ID - citeulike:368203 L3 - citeulike-article-id:368203 TI - Progress in Modeling of Protein Structures and Interactions JF - Science VL - 310 IS - 5748 SP - 638 EP - 642 N2 - The prediction of the structures and interactions of biological macromolecules at the atomic level and the design of new structures and interactions are critical tests of our understanding of the interatomic interactions that underlie molecular biology. Equally important, the capability to accurately predict and design macromolecular structures and interactions would streamline the interpretation of genome sequence information and allow the creation of macromolecules with new and useful functions. This review summarizes recent progress in modeling that suggests that we are entering an era in which high-resolution prediction and design will make increasingly important contributions to biology and medicine. KW - pfc3 KW - review KW - structural_modeling AU - Schueler-Furman, Ora AU - Wang, Chu AU - Bradley, Phil AU - Misura, Kira AU - Baker, David PY - 2005/10/28/ UR - http://dx.doi.org/10.1126/science.1112160 ER -

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