From The Cover: Epigenetic differences arise during the lifetime of monozygotic twins

@article{citeulike:2257911, abstract = {Monozygous twins share a common genotype. However, most monozygotic twin pairs are not identical; several types of phenotypic discordance may be observed, such as differences in susceptibilities to disease and a wide range of anthropomorphic features. There are several possible explanations for these observations, but one is the existence of epigenetic differences. To address this issue, we examined the global and locus-specific differences in DNA methylation and histone acetylation of a large cohort of monozygotic twins. We found that, although twins are epigenetically indistinguishable during the early years of life, older monozygous twins exhibited remarkable differences in their overall content and genomic distribution of 5-methylcytosine DNA and histone acetylation, affecting their gene-expression portrait. These findings indicate how an appreciation of epigenetics is missing from our understanding of how different phenotypes can be originated from the same genotype. 10.1073/pnas.0500398102}, author = {Fraga, Mario F. and Ballestar, Esteban and Paz, Maria F. and Ropero, Santiago and Setien, Fernando and Ballestar, Maria L. and Heine-Suner, Damia and Cigudosa, Juan C. and Urioste, Miguel and Benitez, Javier and Boix-Chornet, Manuel and Sanchez-Aguilera, Abel and Ling, Charlotte and Carlsson, Emma and Poulsen, Pernille and Vaag, Allan and Stephan, Zarko and Spector, Tim D. and Wu, Yue-Zhong and Plass, Christoph and Esteller, Manel }, citeulike-article-id = {2257911}, comment = {Recent twin studies suggest that both environmental influences (Fraga et al., 2005) and genetic variation (Heijmans et al., 2007) influence epigenetic variation. It will be a daunting bioinformatic task to distill putative functional connections from the integration of epigenome data with gene expression profiles and haplotype maps for a large sample from a heterogeneous population. - Bock et al 2007}, doi = {10.1073/pnas.0500398102}, journal = {Proceedings of the National Academy of Sciences}, keywords = {methylation}, month = {July}, number = {30}, pages = {10604--10609}, posted-at = {2008-01-19 19:52:52}, priority = {2}, title = {From The Cover: Epigenetic differences arise during the lifetime of monozygotic twins}, url = {http://dx.doi.org/10.1073/pnas.0500398102}, volume = {102}, year = {2005} }

TY - JOUR ID - citeulike:2257911 L3 - citeulike-article-id:2257911 TI - From The Cover: Epigenetic differences arise during the lifetime of monozygotic twins JF - Proceedings of the National Academy of Sciences VL - 102 IS - 30 SP - 10604 EP - 10609 N2 - Monozygous twins share a common genotype. However, most monozygotic twin pairs are not identical; several types of phenotypic discordance may be observed, such as differences in susceptibilities to disease and a wide range of anthropomorphic features. There are several possible explanations for these observations, but one is the existence of epigenetic differences. To address this issue, we examined the global and locus-specific differences in DNA methylation and histone acetylation of a large cohort of monozygotic twins. We found that, although twins are epigenetically indistinguishable during the early years of life, older monozygous twins exhibited remarkable differences in their overall content and genomic distribution of 5-methylcytosine DNA and histone acetylation, affecting their gene-expression portrait. These findings indicate how an appreciation of epigenetics is missing from our understanding of how different phenotypes can be originated from the same genotype. 10.1073/pnas.0500398102 KW - methylation N1 - Recent twin studies suggest that both environmental influences (Fraga et al., 2005) and genetic variation (Heijmans et al., 2007) influence epigenetic variation. It will be a daunting bioinformatic task to distill putative functional connections from the integration of epigenome data with gene expression profiles and haplotype maps for a large sample from a heterogeneous population. - Bock et al 2007 AU - Fraga, Mario AU - Ballestar, Esteban AU - Paz, Maria AU - Ropero, Santiago AU - Setien, Fernando AU - Ballestar, Maria AU - Heine-Suner, Damia AU - Cigudosa, Juan AU - Urioste, Miguel AU - Benitez, Javier AU - Boix-Chornet, Manuel AU - Sanchez-Aguilera, Abel AU - Ling, Charlotte AU - Carlsson, Emma AU - Poulsen, Pernille AU - Vaag, Allan AU - Stephan, Zarko AU - Spector, Tim AU - Wu, Yue-Zhong AU - Plass, Christoph AU - Esteller, Manel PY - 2005/07/26/ UR - http://dx.doi.org/10.1073/pnas.0500398102 ER -