Increase in activity during calorie restriction requires Sirt1.

@article{citeulike:842243, abstract = {Sir2 (silent information regulator 2) is a nicotinamide adenine dinucleotide-dependent deacetylase required for longevity due to calorie restriction in yeast and Drosophila. In mammals, calorie restriction induces a complex pattern of physiological and behavioral changes. Here we report that the mammalian Sir2 ortholog, Sirt1, is required for the induction of a phenotype by calorie restriction in mice.}, address = {Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.}, author = {Chen, D. and Steele, A. D. and Lindquist, S. and Guarente, L. }, citeulike-article-id = {842243}, doi = {http://dx.doi.org/10.1126/science.1118357}, issn = {1095-9203}, journal = {Science}, keywords = {aging, caloric\_restriction, nicotinamide, sirt1}, month = {December}, number = {5754}, posted-at = {2006-09-13 22:20:54}, priority = {3}, title = {Increase in activity during calorie restriction requires Sirt1.}, url = {http://dx.doi.org/10.1126/science.1118357}, volume = {310}, year = {2005} }

TY - JOUR ID - citeulike:842243 L3 - citeulike-article-id:842243 TI - Increase in activity during calorie restriction requires Sirt1. JF - Science VL - 310 IS - 5754 AD - Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. SN - 1095-9203 N2 - Sir2 (silent information regulator 2) is a nicotinamide adenine dinucleotide-dependent deacetylase required for longevity due to calorie restriction in yeast and Drosophila. In mammals, calorie restriction induces a complex pattern of physiological and behavioral changes. Here we report that the mammalian Sir2 ortholog, Sirt1, is required for the induction of a phenotype by calorie restriction in mice. KW - aging KW - caloric_restriction KW - nicotinamide KW - sirt1 AU - Chen, D AU - Steele, AD AU - Lindquist, S AU - Guarente, L PY - 2005/12/09/ UR - http://dx.doi.org/10.1126/science.1118357 ER -