The gamma -Glutamyl Cycle: A Possible Transport System for Amino Acids

@article{citeulike:654715, abstract = {Evidence is presented that rat kidney contains enzymes that catalyze the synthesis and utilization of glutathione; these reactions, which involve the uptake and release of amino acids from [gamma] -glutamyl linkage, constitute a cyclical process which is termed ``the [gamma] -glutamyl cycle.'' The [gamma] -glutamyl cycle has properties that fulfill the requirements of an amino acid transport system. Thus, [gamma] -glutamyl transpeptidase may function in translocation and [gamma] -glutamyl-cysteine synthetase and glutathione synthetase may catalyze energy-requiring ``recovery'' steps in transport. These and other considerations suggest that glutathione serves a carrier function in amino acid transport.}, author = {Orlowski, Marian and Meister, Alton }, citeulike-article-id = {654715}, journal = {PNAS}, keywords = {aminoacidtransport, gammaglutaymlcycle, glutathione}, month = {November}, number = {3}, pages = {1248--1255}, posted-at = {2006-05-18 20:10:42}, priority = {4}, title = {The gamma -Glutamyl Cycle: A Possible Transport System for Amino Acids}, url = {http://www.pnas.org/cgi/content/abstract/67/3/1248}, volume = {67}, year = {1970} }

TY - JOUR ID - citeulike:654715 L3 - citeulike-article-id:654715 TI - The gamma -Glutamyl Cycle: A Possible Transport System for Amino Acids JF - PNAS VL - 67 IS - 3 SP - 1248 EP - 1255 N2 - Evidence is presented that rat kidney contains enzymes that catalyze the synthesis and utilization of glutathione; these reactions, which involve the uptake and release of amino acids from [gamma] -glutamyl linkage, constitute a cyclical process which is termed ``the [gamma] -glutamyl cycle.'' The [gamma] -glutamyl cycle has properties that fulfill the requirements of an amino acid transport system. Thus, [gamma] -glutamyl transpeptidase may function in translocation and [gamma] -glutamyl-cysteine synthetase and glutathione synthetase may catalyze energy-requiring ``recovery'' steps in transport. These and other considerations suggest that glutathione serves a carrier function in amino acid transport. KW - aminoacidtransport KW - gammaglutaymlcycle KW - glutathione AU - Orlowski, Marian AU - Meister, Alton PY - 1970/11/01/ UR - http://www.pnas.org/cgi/content/abstract/67/3/1248 ER -