Invertebrate 7SK snRNAs

by: Andreas Gruber, Dorota Koper-Emde, Manja Marz, Hakim Tafer, Stephan Bernhart, Gregor Obernosterer, Axel Mosig, Ivo Hofacker, Peter Stadler, Bernd-Joachim Benecke

Journal of Molecular Evolution, Vol. 66, No. 2. (20 February 2008), pp. 107-115.

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Abstract

Abstract 7SK RNA is a highly abundant noncoding RNA in mammalian cells whose function in transcriptional regulation has only recently been elucidated. Despite its highly conserved sequence throughout vertebrates, all attempts to discover 7SK RNA homologues in invertebrate species have failed so far. Here we report on a combined experimental and computational survey that succeeded in discovering 7SK RNAs in most of the major deuterostome clades and in two protostome phyla: mollusks and annelids. Despite major efforts, no candidates were found in any of the many available ecdysozoan genomes, however. The additional sequence data confirm the evolutionary conservation and hence functional importance of the previously described 3′ and 5′ stem-loop motifs, and provide evidence for a third, structurally well-conserved domain.

@article{citeulike:2591123, abstract = {Abstract\ \ 7SK RNA is a highly abundant noncoding RNA in mammalian cells whose function in transcriptional regulation has only recently been elucidated. Despite its highly conserved sequence throughout vertebrates, all attempts to discover 7SK RNA homologues in invertebrate species have failed so far. Here we report on a combined experimental and computational survey that succeeded in discovering 7SK RNAs in most of the major deuterostome clades and in two protostome phyla: mollusks and annelids. Despite major efforts, no candidates were found in any of the many available ecdysozoan genomes, however. The additional sequence data confirm the evolutionary conservation and hence functional importance of the previously described 3′ and 5′ stem-loop motifs, and provide evidence for a third, structurally well-conserved domain.}, author = {Gruber, Andreas and Koper-Emde, Dorota and Marz, Manja and Tafer, Hakim and Bernhart, Stephan and Obernosterer, Gregor and Mosig, Axel and Hofacker, Ivo and Stadler, Peter and Benecke, Bernd-Joachim }, citeulike-article-id = {2591123}, doi = {http://dx.doi.org/10.1007/s00239-007-9052-6}, journal = {Journal of Molecular Evolution}, month = {February}, number = {2}, pages = {107--115}, posted-at = {2008-03-26 11:05:17}, priority = {0}, title = {Invertebrate 7SK snRNAs}, url = {http://dx.doi.org/10.1007/s00239-007-9052-6}, volume = {66}, year = {2008} }

RIS record

TY - JOUR ID - citeulike:2591123 L3 - citeulike-article-id:2591123 TI - Invertebrate 7SK snRNAs JF - Journal of Molecular Evolution VL - 66 IS - 2 SP - 107 EP - 115 N2 - Abstract  7SK RNA is a highly abundant noncoding RNA in mammalian cells whose function in transcriptional regulation has only recently been elucidated. Despite its highly conserved sequence throughout vertebrates, all attempts to discover 7SK RNA homologues in invertebrate species have failed so far. Here we report on a combined experimental and computational survey that succeeded in discovering 7SK RNAs in most of the major deuterostome clades and in two protostome phyla: mollusks and annelids. Despite major efforts, no candidates were found in any of the many available ecdysozoan genomes, however. The additional sequence data confirm the evolutionary conservation and hence functional importance of the previously described 3′ and 5′ stem-loop motifs, and provide evidence for a third, structurally well-conserved domain. AU - Gruber, Andreas AU - Koper-Emde, Dorota AU - Marz, Manja AU - Tafer, Hakim AU - Bernhart, Stephan AU - Obernosterer, Gregor AU - Mosig, Axel AU - Hofacker, Ivo AU - Stadler, Peter AU - Benecke, Bernd-Joachim PY - 2008/02/20/ UR - http://dx.doi.org/10.1007/s00239-007-9052-6 ER -

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