Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes.

by: S Baskerville, DP Bartel

RNA, Vol. 11, No. 3. (March 2005), pp. 241-247.

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Abstract

MicroRNAs (miRNAs) are short endogenous RNAs known to post-transcriptionally repress gene expression in animals and plants. A microarray profiling survey revealed the expression patterns of 175 human miRNAs across 24 different human organs. Our results show that proximal pairs of miRNAs are generally coexpressed. In addition, an abrupt transition in the correlation between pairs of expressed miRNAs occurs at a distance of 50 kb, implying that miRNAs separated by <50 kb typically derive from a common transcript. Some microRNAs are within the introns of host genes. Intronic miRNAs are usually coordinately expressed with their host gene mRNA, implying that they also generally derive from a common transcript, and that in situ analyses of host gene expression can be used to probe the spatial and temporal localization of intronic miRNAs.

@article{citeulike:756519, abstract = {MicroRNAs (miRNAs) are short endogenous RNAs known to post-transcriptionally repress gene expression in animals and plants. A microarray profiling survey revealed the expression patterns of 175 human miRNAs across 24 different human organs. Our results show that proximal pairs of miRNAs are generally coexpressed. In addition, an abrupt transition in the correlation between pairs of expressed miRNAs occurs at a distance of 50 kb, implying that miRNAs separated by <50 kb typically derive from a common transcript. Some microRNAs are within the introns of host genes. Intronic miRNAs are usually coordinately expressed with their host gene mRNA, implying that they also generally derive from a common transcript, and that in situ analyses of host gene expression can be used to probe the spatial and temporal localization of intronic miRNAs.}, address = {Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA.}, author = {Baskerville, S. and Bartel, D. P. }, citeulike-article-id = {756519}, doi = {http://dx.doi.org/10.1261/rna.7240905}, issn = {1355-8382}, journal = {RNA}, keywords = {microrna, microrna\_expression}, month = {March}, number = {3}, pages = {241--247}, posted-at = {2008-01-15 14:45:38}, priority = {3}, title = {Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes.}, url = {http://dx.doi.org/10.1261/rna.7240905}, volume = {11}, year = {2005} }

RIS record

TY - JOUR ID - citeulike:756519 L3 - citeulike-article-id:756519 TI - Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes. JF - RNA VL - 11 IS - 3 SP - 241 EP - 247 AD - Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA. SN - 1355-8382 N2 - MicroRNAs (miRNAs) are short endogenous RNAs known to post-transcriptionally repress gene expression in animals and plants. A microarray profiling survey revealed the expression patterns of 175 human miRNAs across 24 different human organs. Our results show that proximal pairs of miRNAs are generally coexpressed. In addition, an abrupt transition in the correlation between pairs of expressed miRNAs occurs at a distance of 50 kb, implying that miRNAs separated by <50 kb typically derive from a common transcript. Some microRNAs are within the introns of host genes. Intronic miRNAs are usually coordinately expressed with their host gene mRNA, implying that they also generally derive from a common transcript, and that in situ analyses of host gene expression can be used to probe the spatial and temporal localization of intronic miRNAs. KW - microrna KW - microrna_expression AU - Baskerville, S AU - Bartel, DP PY - 2005/03// UR - http://dx.doi.org/10.1261/rna.7240905 ER -

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