Smad transcription factors.

@article{citeulike:483211, abstract = {Smad transcription factors lie at the core of one of the most versatile cytokine signaling pathways in metazoan biology-the transforming growth factor-beta (TGFbeta) pathway. Recent progress has shed light into the processes of Smad activation and deactivation, nucleocytoplasmic dynamics, and assembly of transcriptional complexes. A rich repertoire of regulatory devices exerts control over each step of the Smad pathway. This knowledge is enabling work on more complex questions about the organization, integration, and modulation of Smad-dependent transcriptional programs. We are beginning to uncover self-enabled gene response cascades, graded Smad response mechanisms, and Smad-dependent synexpression groups. Our growing understanding of TGFbeta signaling through the Smad pathway provides general principles for how animal cells translate complex inputs into concrete behavior.}, address = {Cancer Biology and Genetics Program, Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. massaguj@mskcc.org}, author = {Massagu\'{e}, J. and Seoane, J. and Wotton, D. }, citeulike-article-id = {483211}, doi = {10.1101/gad.1350705}, issn = {0890-9369}, journal = {Genes Dev}, keywords = {smad, transcription\_factor}, month = {December}, number = {23}, pages = {2783--2810}, posted-at = {2008-04-25 12:21:40}, priority = {2}, title = {Smad transcription factors.}, url = {http://dx.doi.org/10.1101/gad.1350705}, volume = {19}, year = {2005} }

TY - JOUR ID - citeulike:483211 L3 - citeulike-article-id:483211 TI - Smad transcription factors. JF - Genes Dev VL - 19 IS - 23 SP - 2783 EP - 2810 AD - Cancer Biology and Genetics Program, Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. massaguj@mskcc.org SN - 0890-9369 N2 - Smad transcription factors lie at the core of one of the most versatile cytokine signaling pathways in metazoan biology-the transforming growth factor-beta (TGFbeta) pathway. Recent progress has shed light into the processes of Smad activation and deactivation, nucleocytoplasmic dynamics, and assembly of transcriptional complexes. A rich repertoire of regulatory devices exerts control over each step of the Smad pathway. This knowledge is enabling work on more complex questions about the organization, integration, and modulation of Smad-dependent transcriptional programs. We are beginning to uncover self-enabled gene response cascades, graded Smad response mechanisms, and Smad-dependent synexpression groups. Our growing understanding of TGFbeta signaling through the Smad pathway provides general principles for how animal cells translate complex inputs into concrete behavior. KW - smad KW - transcription_factor AU - Massagué, J AU - Seoane, J AU - Wotton, D PY - 2005/12/01/ UR - http://dx.doi.org/10.1101/gad.1350705 ER -