Gene Regulation by Transcription Factors and MicroRNAs

by: Oliver Hobert

Science, Vol. 319, No. 5871. (28 March 2008), pp. 1785-1786.

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Abstract

The properties of a cell are determined by the genetic information encoded in its genome. Understanding how such information is differentially and dynamically retrieved to define distinct cell types and cellular states is a major challenge facing molecular biology. Gene regulatory factors that control the expression of genomic information come in a variety of flavors, with transcription factors and microRNAs representing the most numerous gene regulatory factors in multicellular genomes. Here, I review common principles of transcription factor and microRNA-mediated gene regulatory events and discuss conceptual differences in how these factors control gene expression. 10.1126/science.1151651

@article{citeulike:2607632, abstract = {The properties of a cell are determined by the genetic information encoded in its genome. Understanding how such information is differentially and dynamically retrieved to define distinct cell types and cellular states is a major challenge facing molecular biology. Gene regulatory factors that control the expression of genomic information come in a variety of flavors, with transcription factors and microRNAs representing the most numerous gene regulatory factors in multicellular genomes. Here, I review common principles of transcription factor and microRNA-mediated gene regulatory events and discuss conceptual differences in how these factors control gene expression. 10.1126/science.1151651}, author = {Hobert, Oliver }, citeulike-article-id = {2607632}, doi = {10.1126/science.1151651}, journal = {Science}, keywords = {microrna, review}, month = {March}, number = {5871}, pages = {1785--1786}, posted-at = {2008-03-28 15:00:58}, priority = {4}, title = {Gene Regulation by Transcription Factors and MicroRNAs}, url = {http://dx.doi.org/10.1126/science.1151651}, volume = {319}, year = {2008} }

RIS record

TY - JOUR ID - citeulike:2607632 L3 - citeulike-article-id:2607632 TI - Gene Regulation by Transcription Factors and MicroRNAs JF - Science VL - 319 IS - 5871 SP - 1785 EP - 1786 N2 - The properties of a cell are determined by the genetic information encoded in its genome. Understanding how such information is differentially and dynamically retrieved to define distinct cell types and cellular states is a major challenge facing molecular biology. Gene regulatory factors that control the expression of genomic information come in a variety of flavors, with transcription factors and microRNAs representing the most numerous gene regulatory factors in multicellular genomes. Here, I review common principles of transcription factor and microRNA-mediated gene regulatory events and discuss conceptual differences in how these factors control gene expression. 10.1126/science.1151651 KW - microrna KW - review AU - Hobert, Oliver PY - 2008/03/28/ UR - http://dx.doi.org/10.1126/science.1151651 ER -

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