The Piwi-piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race

@article{citeulike:1867241, abstract = {Increasingly complex networks of small RNAs act through RNA-interference (RNAi) pathways to regulate gene expression, to mediate antiviral responses, to organize chromosomal domains, and to restrain the spread of selfish genetic elements. Historically, RNAi has been defined as a response to double-stranded RNA. However, some small RNA species may not arise from double-stranded RNA precursors. Yet, like microRNAs and small interfering RNAs, such species guide Argonaute proteins to silencing targets through complementary base-pairing. Silencing can be achieved by corecruitment of accessory factors or through the activity of Argonaute itself, which often has endonucleolytic activity. As a specific and adaptive regulatory system, RNAi is used throughout eukarya, which indicates a long evolutionary history. A likely function of RNAi throughout that history is to protect the genome from both pathogenic and parasitic invaders. 10.1126/science.1146484}, author = {Aravin, Alexei A. and Hannon, Gregory J. and Brennecke, Julius }, citeulike-article-id = {1867241}, doi = {10.1126/science.1146484}, journal = {Science}, keywords = {pirna, review}, month = {November}, number = {5851}, pages = {761--764}, posted-at = {2007-11-09 09:44:03}, priority = {2}, title = {The Piwi-piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race}, url = {http://dx.doi.org/10.1126/science.1146484}, volume = {318}, year = {2007} }

TY - JOUR ID - citeulike:1867241 L3 - citeulike-article-id:1867241 TI - The Piwi-piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race JF - Science VL - 318 IS - 5851 SP - 761 EP - 764 N2 - Increasingly complex networks of small RNAs act through RNA-interference (RNAi) pathways to regulate gene expression, to mediate antiviral responses, to organize chromosomal domains, and to restrain the spread of selfish genetic elements. Historically, RNAi has been defined as a response to double-stranded RNA. However, some small RNA species may not arise from double-stranded RNA precursors. Yet, like microRNAs and small interfering RNAs, such species guide Argonaute proteins to silencing targets through complementary base-pairing. Silencing can be achieved by corecruitment of accessory factors or through the activity of Argonaute itself, which often has endonucleolytic activity. As a specific and adaptive regulatory system, RNAi is used throughout eukarya, which indicates a long evolutionary history. A likely function of RNAi throughout that history is to protect the genome from both pathogenic and parasitic invaders. 10.1126/science.1146484 KW - pirna KW - review AU - Aravin, Alexei AU - Hannon, Gregory AU - Brennecke, Julius PY - 2007/11/02/ UR - http://dx.doi.org/10.1126/science.1146484 ER -