Variable gene expression in eukaryotes: a network perspective

by: Patricia J Wittkopp

J Exp Biol, Vol. 210, No. 9. (1 May 2007), pp. 1567-1575.

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Abstract

Changes in gene expression underlie phenotypic plasticity, variation within species, and phenotypic divergence between species. These expression differences arise from modulation of regulatory networks. To understand the source of expression differences, networks of interactions among genes and gene products that orchestrate gene expression must be considered. Here I review the basic structure of eukaryotic regulatory networks and discuss selected case studies that provide insight into how these networks are altered to create expression differences within and between species. 10.1242/jeb.002592

@article{citeulike:1836040, abstract = {Changes in gene expression underlie phenotypic plasticity, variation within species, and phenotypic divergence between species. These expression differences arise from modulation of regulatory networks. To understand the source of expression differences, networks of interactions among genes and gene products that orchestrate gene expression must be considered. Here I review the basic structure of eukaryotic regulatory networks and discuss selected case studies that provide insight into how these networks are altered to create expression differences within and between species. 10.1242/jeb.002592}, address = {Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA}, author = {Wittkopp, Patricia J. }, citeulike-article-id = {1836040}, doi = {10.1242/jeb.002592}, journal = {J Exp Biol}, keywords = {genetic\_regulatory\_network}, month = {May}, number = {9}, pages = {1567--1575}, posted-at = {2008-01-15 14:58:28}, priority = {3}, publisher = {The Company of Biologists}, title = {Variable gene expression in eukaryotes: a network perspective}, url = {http://dx.doi.org/10.1242/jeb.002592}, volume = {210}, year = {2007} }

RIS record

TY - JOUR ID - citeulike:1836040 L3 - citeulike-article-id:1836040 TI - Variable gene expression in eukaryotes: a network perspective JF - J Exp Biol VL - 210 IS - 9 SP - 1567 EP - 1575 AD - Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA PB - The Company of Biologists N2 - Changes in gene expression underlie phenotypic plasticity, variation within species, and phenotypic divergence between species. These expression differences arise from modulation of regulatory networks. To understand the source of expression differences, networks of interactions among genes and gene products that orchestrate gene expression must be considered. Here I review the basic structure of eukaryotic regulatory networks and discuss selected case studies that provide insight into how these networks are altered to create expression differences within and between species. 10.1242/jeb.002592 KW - genetic_regulatory_network AU - Wittkopp, Patricia PY - 2007/05/01/ UR - http://dx.doi.org/10.1242/jeb.002592 ER -

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