MicroRNA regulation and interspecific variation of gene expression.

by: Qinghua Cui, Zhenbao Yu, Enrico OO Purisima, Edwin Wang

Trends in Genetics, Vol. 23, No. 8. (3 May 2007), pp. 372-375.

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Abstract

MicroRNAs (miRNAs) modulate expression of their target genes in various tissues and at different developmental stages, but it is unclear whether they drive cross-species variation in gene expression. By comparing data from mammal and fly species we found that the cross-species expression variation of miRNA targets is significantly lower than that of other genes. This implies that miRNAs can affect gene expression by reducing stochastic noise, buffering cross-species variation and constraining evolutionary gene expression variation.

@article{citeulike:1283686, abstract = {MicroRNAs (miRNAs) modulate expression of their target genes in various tissues and at different developmental stages, but it is unclear whether they drive cross-species variation in gene expression. By comparing data from mammal and fly species we found that the cross-species expression variation of miRNA targets is significantly lower than that of other genes. This implies that miRNAs can affect gene expression by reducing stochastic noise, buffering cross-species variation and constraining evolutionary gene expression variation.}, address = {Biotechnology Research Institute, National Research Council Canada, Montreal, Quebec, H4P 2R2, Canada.}, author = {Cui, Qinghua and Yu, Zhenbao and Purisima, Enrico O. O. and Wang, Edwin }, citeulike-article-id = {1283686}, doi = {10.1016/j.tig.2007.04.003}, issn = {0168-9525}, journal = {Trends in Genetics}, keywords = {microrna}, month = {May}, number = {8}, pages = {372--375}, posted-at = {2008-01-15 14:59:58}, priority = {3}, publisher = {Elsevier}, title = {MicroRNA regulation and interspecific variation of gene expression.}, url = {http://dx.doi.org/10.1016/j.tig.2007.04.003}, volume = {23}, year = {2007} }

RIS record

TY - JOUR ID - citeulike:1283686 L3 - citeulike-article-id:1283686 TI - MicroRNA regulation and interspecific variation of gene expression. JF - Trends in Genetics VL - 23 IS - 8 SP - 372 EP - 375 AD - Biotechnology Research Institute, National Research Council Canada, Montreal, Quebec, H4P 2R2, Canada. PB - Elsevier SN - 0168-9525 N2 - MicroRNAs (miRNAs) modulate expression of their target genes in various tissues and at different developmental stages, but it is unclear whether they drive cross-species variation in gene expression. By comparing data from mammal and fly species we found that the cross-species expression variation of miRNA targets is significantly lower than that of other genes. This implies that miRNAs can affect gene expression by reducing stochastic noise, buffering cross-species variation and constraining evolutionary gene expression variation. KW - microrna AU - Cui, Qinghua AU - Yu, Zhenbao AU - Purisima, Enrico AU - Wang, Edwin PY - 2007/05/03/ UR - http://dx.doi.org/10.1016/j.tig.2007.04.003 ER -

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