Division of labor among distinct subtypes of inhibitory neurons in a cortical microcircuit of working memory.

@article{citeulike:968861, abstract = {A conspicuous feature of cortical organization is the wide diversity of inhibitory interneurons; their differential computational functions remain unclear. Here we propose a local cortical circuit in which three major subtypes of interneurons play distinct roles. In a model designed for spatial working memory, stimulus tuning of persistent activity arises from the concerted action of widespread inhibition mediated by perisoma-targeting (parvalbumin-containing) interneurons and localized disinhibition of pyramidal cells via interneuron-targeting (calretinin-containing) interneurons. Moreover, resistance against distracting stimuli (a fundamental property of working memory) is dynamically controlled by dendrite-targeting (calbindin-containing) interneurons. The experimental observation of inverted tuning curves of monkey prefrontal neurons recorded during working memory supports a key model prediction. This work suggests a framework for understanding the division of labor and cooperation among different inhibitory cell types in a recurrent cortical circuit.}, address = {Center for Complex Systems, Brandeis University, Waltham, MA 02254, USA. xjwang@brandeis.edu}, author = {Wang, X. J. and Tegn\'{e}r, J. and Constantinidis, C. and Goldman-Rakic, P. S. }, citeulike-article-id = {968861}, doi = {10.1073/pnas.0305337101}, issn = {0027-8424}, journal = {Proc Natl Acad Sci U S A}, keywords = {heterogeneity, inhibition, microcircuits, network\_dynamics, working\_memory}, month = {February}, number = {5}, pages = {1368--1373}, posted-at = {2008-05-13 16:13:33}, priority = {2}, title = {Division of labor among distinct subtypes of inhibitory neurons in a cortical microcircuit of working memory.}, url = {http://dx.doi.org/10.1073/pnas.0305337101}, volume = {101}, year = {2004} }

TY - JOUR ID - citeulike:968861 L3 - citeulike-article-id:968861 TI - Division of labor among distinct subtypes of inhibitory neurons in a cortical microcircuit of working memory. JF - Proc Natl Acad Sci U S A VL - 101 IS - 5 SP - 1368 EP - 1373 AD - Center for Complex Systems, Brandeis University, Waltham, MA 02254, USA. xjwang@brandeis.edu SN - 0027-8424 N2 - A conspicuous feature of cortical organization is the wide diversity of inhibitory interneurons; their differential computational functions remain unclear. Here we propose a local cortical circuit in which three major subtypes of interneurons play distinct roles. In a model designed for spatial working memory, stimulus tuning of persistent activity arises from the concerted action of widespread inhibition mediated by perisoma-targeting (parvalbumin-containing) interneurons and localized disinhibition of pyramidal cells via interneuron-targeting (calretinin-containing) interneurons. Moreover, resistance against distracting stimuli (a fundamental property of working memory) is dynamically controlled by dendrite-targeting (calbindin-containing) interneurons. The experimental observation of inverted tuning curves of monkey prefrontal neurons recorded during working memory supports a key model prediction. This work suggests a framework for understanding the division of labor and cooperation among different inhibitory cell types in a recurrent cortical circuit. KW - heterogeneity KW - inhibition KW - microcircuits KW - network_dynamics KW - working_memory AU - Wang, XJ AU - Tegnér, J AU - Constantinidis, C AU - Goldman-Rakic, PS PY - 2004/02/03/ UR - http://dx.doi.org/10.1073/pnas.0305337101 ER -