Spike-timing-dependent synaptic modification induced by natural spike trains.

@article{citeulike:796941, abstract = {The strength of the connection between two neurons can be modified by activity, in a way that depends on the timing of neuronal firing on either side of the synapse. This spike-timing-dependent plasticity (STDP) has been studied by systematically varying the intervals between pre- and postsynaptic spikes. Here we studied how STDP operates in the context of more natural spike trains. We found that in visual cortical slices the contribution of each pre-/postsynaptic spike pair to synaptic modification depends not only on the interval between the pair, but also on the timing of preceding spikes. The efficacy of each spike in synaptic modification was suppressed by the preceding spike in the same neuron, occurring within several tens of milliseconds. The direction and magnitude of synaptic modifications induced by spike patterns recorded in vivo in response to natural visual stimuli were well predicted by incorporating the suppressive inter-spike interaction within each neuron. Thus, activity-induced synaptic modification depends not only on the relative spike timing between the neurons, but also on the spiking pattern within each neuron. For natural spike trains, the timing of the first spike in each burst is dominant in synaptic modification.}, address = {Division of Neurobiology, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA.}, author = {Froemke, R. C. and Dan, Y. }, citeulike-article-id = {796941}, doi = {http://dx.doi.org/10.1038/416433a}, issn = {0028-0836}, journal = {Nature}, keywords = {stdp, synaptic\_dynamics, synaptic\_plasticity, temporal\_coding}, month = {March}, number = {6879}, pages = {433--438}, posted-at = {2008-05-13 16:48:07}, priority = {2}, title = {Spike-timing-dependent synaptic modification induced by natural spike trains.}, url = {http://dx.doi.org/10.1038/416433a}, volume = {416}, year = {2002} }

TY - JOUR ID - citeulike:796941 L3 - citeulike-article-id:796941 TI - Spike-timing-dependent synaptic modification induced by natural spike trains. JF - Nature VL - 416 IS - 6879 SP - 433 EP - 438 AD - Division of Neurobiology, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA. SN - 0028-0836 N2 - The strength of the connection between two neurons can be modified by activity, in a way that depends on the timing of neuronal firing on either side of the synapse. This spike-timing-dependent plasticity (STDP) has been studied by systematically varying the intervals between pre- and postsynaptic spikes. Here we studied how STDP operates in the context of more natural spike trains. We found that in visual cortical slices the contribution of each pre-/postsynaptic spike pair to synaptic modification depends not only on the interval between the pair, but also on the timing of preceding spikes. The efficacy of each spike in synaptic modification was suppressed by the preceding spike in the same neuron, occurring within several tens of milliseconds. The direction and magnitude of synaptic modifications induced by spike patterns recorded in vivo in response to natural visual stimuli were well predicted by incorporating the suppressive inter-spike interaction within each neuron. Thus, activity-induced synaptic modification depends not only on the relative spike timing between the neurons, but also on the spiking pattern within each neuron. For natural spike trains, the timing of the first spike in each burst is dominant in synaptic modification. KW - stdp KW - synaptic_dynamics KW - synaptic_plasticity KW - temporal_coding AU - Froemke, RC AU - Dan, Y PY - 2002/03/28/ UR - http://dx.doi.org/10.1038/416433a ER -