An adaptive spike-timing-dependent plasticity rule

by: Jesper Tegnér, Ádám Kepecs

Neurocomputing, Vol. 44-46 (June 2002), pp. 189-194.

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Abstract

We examine the conditions under which spike-timing-dependent plasticity (STDP) normalizes post-synaptic firing rates. Our simulations show that the rate normalization property of STDP is fragile and small changes in the LTD/LTP ratio or pre-synaptic input rates can lead to high firing rates. We propose an adaptive scheme to dynamically control the LTP/LTD ratio. The biophysics of synapses lead us to suggest a control mechanism using action potential-induced calcium influx, a known mediator of synaptic plasticity. This adaptive STDP rule is shown to stabilize the post-synaptic firing rates under a variety of perturbations.

@article{citeulike:2795222, abstract = {We examine the conditions under which spike-timing-dependent plasticity (STDP) normalizes post-synaptic firing rates. Our simulations show that the rate normalization property of STDP is fragile and small changes in the LTD/LTP ratio or pre-synaptic input rates can lead to high firing rates. We propose an adaptive scheme to dynamically control the LTP/LTD ratio. The biophysics of synapses lead us to suggest a control mechanism using action potential-induced calcium influx, a known mediator of synaptic plasticity. This adaptive STDP rule is shown to stabilize the post-synaptic firing rates under a variety of perturbations.}, author = {Tegn\'{e}r, Jesper and Kepecs, \'{A}d\'{a}m }, citeulike-article-id = {2795222}, doi = {http://dx.doi.org/10.1016/S0925-2312(02)00393-4}, journal = {Neurocomputing}, keywords = {homeostasis, stdp, synaptic\_plasticity}, month = {June}, pages = {189--194}, posted-at = {2008-05-13 15:50:53}, priority = {2}, title = {An adaptive spike-timing-dependent plasticity rule}, url = {http://dx.doi.org/10.1016/S0925-2312(02)00393-4}, volume = {44-46}, year = {2002} }

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TY - JOUR ID - citeulike:2795222 L3 - citeulike-article-id:2795222 TI - An adaptive spike-timing-dependent plasticity rule JF - Neurocomputing VL - 44-46 SP - 189 EP - 194 N2 - We examine the conditions under which spike-timing-dependent plasticity (STDP) normalizes post-synaptic firing rates. Our simulations show that the rate normalization property of STDP is fragile and small changes in the LTD/LTP ratio or pre-synaptic input rates can lead to high firing rates. We propose an adaptive scheme to dynamically control the LTP/LTD ratio. The biophysics of synapses lead us to suggest a control mechanism using action potential-induced calcium influx, a known mediator of synaptic plasticity. This adaptive STDP rule is shown to stabilize the post-synaptic firing rates under a variety of perturbations. KW - homeostasis KW - stdp KW - synaptic_plasticity AU - Tegnér, Jesper AU - Kepecs, Ádám PY - 2002/06// UR - http://dx.doi.org/10.1016/S0925-2312(02)00393-4 ER -

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