Hypoadiponectinemia as a predictor for the development of hypertension: a 5-year prospective study.

@article{citeulike:2924083, abstract = {Low circulating levels of adiponectin, an adipokine with insulin-sensitizing, antiatherogenic, and anti-inflammatory properties, are found in hypertensive patients. Adiponectin replenishment ameliorated hypertension in adiponectin-deficient mice or obese, hypertensive mice with hypoadiponectinemia, suggesting an etiologic role of adiponectin in hypertension. We aimed to determine, in this 5-year prospective study, whether hypoadiponectinemia could predict the development of hypertension in a nondiabetic Chinese cohort. A total of 577 subjects (249 men and 328 women) were recruited from the population-based Hong Kong Cardiovascular Risk Factor Prevalence Study and prospectively followed up for 5 years. The relationship of serum adiponectin with the development of hypertension (sitting blood pressure >or=140/90 mm Hg) was investigated in a nested case-control study consisting of 70 subjects who had developed hypertension on follow-up and 140 age- and sex-matched control subjects who were normotensive both at baseline and at year 5. At baseline, serum adiponectin level in the lowest sex-specific tertile was more likely to be associated with hypertension (P=0.003 versus the highest tertile, after adjusting for age, body mass index, fasting insulin, and high-sensitivity C-reactive protein). At year 5, baseline serum adiponectin was a significant independent predictor of incident hypertension in the nested case-control study (P=0.015; age adjusted), together with mean arterial pressure (P<0.001), high-sensitivity C-reactive protein (P=0.018), and body mass index (P=0.004). Normotensive subjects with baseline serum adiponectin levels in the lowest sex-specific tertile had an increased risk of becoming hypertensive (adjusted odds ratio: 2.76; 95\% CIs: 1.06 to 7.16; P=0.037 versus highest tertile). Our data suggest that hypoadiponectinaemia may be involved in the pathogenesis of hypertension in humans.}, address = {Department of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Rd, Hong Kong, People's Republic of China.}, author = {Chow, W. S. and Cheung, B. M. and Tso, A. W. and Xu, A. and Wat, N. M. and Fong, C. H. and Ong, L. H. and Tam, S. and Tan, K. C. and Janus, E. D. and Lam, T. H. and Lam, K. S. }, citeulike-article-id = {2924083}, doi = {http://dx.doi.org/10.1161/HYPERTENSIONAHA.107.086835}, issn = {1524-4563}, journal = {Hypertension}, keywords = {adipokine, aging, cu, cvd}, month = {June}, number = {6}, pages = {1455--1461}, posted-at = {2008-06-24 19:01:04}, priority = {0}, title = {Hypoadiponectinemia as a predictor for the development of hypertension: a 5-year prospective study.}, url = {http://dx.doi.org/10.1161/HYPERTENSIONAHA.107.086835}, volume = {49}, year = {2007} }

TY - JOUR ID - citeulike:2924083 L3 - citeulike-article-id:2924083 TI - Hypoadiponectinemia as a predictor for the development of hypertension: a 5-year prospective study. JF - Hypertension VL - 49 IS - 6 SP - 1455 EP - 1461 AD - Department of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Rd, Hong Kong, People's Republic of China. SN - 1524-4563 N2 - Low circulating levels of adiponectin, an adipokine with insulin-sensitizing, antiatherogenic, and anti-inflammatory properties, are found in hypertensive patients. Adiponectin replenishment ameliorated hypertension in adiponectin-deficient mice or obese, hypertensive mice with hypoadiponectinemia, suggesting an etiologic role of adiponectin in hypertension. We aimed to determine, in this 5-year prospective study, whether hypoadiponectinemia could predict the development of hypertension in a nondiabetic Chinese cohort. A total of 577 subjects (249 men and 328 women) were recruited from the population-based Hong Kong Cardiovascular Risk Factor Prevalence Study and prospectively followed up for 5 years. The relationship of serum adiponectin with the development of hypertension (sitting blood pressure >or=140/90 mm Hg) was investigated in a nested case-control study consisting of 70 subjects who had developed hypertension on follow-up and 140 age- and sex-matched control subjects who were normotensive both at baseline and at year 5. At baseline, serum adiponectin level in the lowest sex-specific tertile was more likely to be associated with hypertension (P=0.003 versus the highest tertile, after adjusting for age, body mass index, fasting insulin, and high-sensitivity C-reactive protein). At year 5, baseline serum adiponectin was a significant independent predictor of incident hypertension in the nested case-control study (P=0.015; age adjusted), together with mean arterial pressure (P<0.001), high-sensitivity C-reactive protein (P=0.018), and body mass index (P=0.004). Normotensive subjects with baseline serum adiponectin levels in the lowest sex-specific tertile had an increased risk of becoming hypertensive (adjusted odds ratio: 2.76; 95% CIs: 1.06 to 7.16; P=0.037 versus highest tertile). Our data suggest that hypoadiponectinaemia may be involved in the pathogenesis of hypertension in humans. KW - adipokine KW - aging KW - cu KW - cvd AU - Chow, WS AU - Cheung, BM AU - Tso, AW AU - Xu, A AU - Wat, NM AU - Fong, CH AU - Ong, LH AU - Tam, S AU - Tan, KC AU - Janus, ED AU - Lam, TH AU - Lam, KS PY - 2007/06// UR - http://dx.doi.org/10.1161/HYPERTENSIONAHA.107.086835 ER -